• Characterisation of a phase-variable restriction-modification system in Enterococcus faecalis 

  Campbell, Isobella

  The gastrointestinal colonizer Enterococcus faecalis is an opportunistic, multi-drug resistant pathogen and a leading cause of nosocomial infections. Vancomycin- resistant enterococci (VRE) are of particular concern and ...

• Aspirin’s role in preventing E-cadherin cleavage by the carcinogenic Bacteroides fragilis toxin 

  Swan, James Raymond

  Carriage of enterotoxigenic Bacteroides fragilis (ETBF) in the colonic mucosa is associated with increased risk of pre-cancerous lesions. Antibiotics will not selectively eradicate these bacteria, but toxin-mediated host ...

• Identification of AH1-specific T cells in a mouse model of colorectal cancer 

  Harte, Jessica Elise

  Colorectal cancer (CRC) causes approximately 1.4 million new cases of disease and 700,000 deaths worldwide annually. To overcome limitations of studying CRC in humans, mouse models are used to test therapeutics such as ...

• Intracellular redox changes during TNFα-mediated necroptosis 

  Heath, Sarah

  Necroptosis is a form of regulated cell death triggered by a variety of factors associated with infection and inflammation. It is distinct from the well-characterised cell death processes of apoptosis and necrosis, sharing ...

• CNVs and familial breast and ovarian cancer 

  Chai, Isabelle

  BRCA1 pathogenic variant carriers experience a high risk of developing breast and ovarian cancer, however, differences in risk vary greatly between individuals. The advent of genetic testing has presented an increasing ...

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