OUR Archive (Otago University Research Archive)
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Identification of synthetic lethal compounds targeting cancers with cohesin mutations
The cohesin complex, comprising four core subunits, RAD21, SMC3, SMC1A, and STAG1/2, is important for the regulation of many biological processes, including sister chromatid cohesion, regulation of gene expression, chromatin ... -
Factors affecting children’s oral care practices during the first 2 years of life
1. Background The main purpose of oral care practices for young children is to prevent dental caries. Oral care practices have 2 components: home care and professional dental care. Home oral care practice involves ... -
The forgotten arm of the fight-flight response: α-adrenergic control of the diabetic heart and interactions with Calmodulin Kinase 2
In Type 2 Diabetes Mellitus (T2DM) chronic metabolic stress and associated hemodynamic dysregulation result in a two-fold increase in cardiovascular disease (CVD) risk, making CVD a leading cause of death for T2DM patients ... -
The Absent Vedas
The Vedas were first described by a European author in a text dating from the 1580s, which was subsequently copied by other authors and appeared in translation in most of the major European languages in the course of the ... -
Cell-penetrating peptides for enhanced oral delivery of nanoformulations
Introduction: Oral drug delivery systems such as polymeric nanoparticles are used to improve therapies that utilize biomacromolecules like proteins and peptides. Surface modifications of polymeric nanoparticles play a ...