• Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146 

    Agbowuro, Ayodeji; Mazraani, Rami; McCaughey, Laura; Huston, Wilhelmina; Gamble, Allan; Tyndall, Joel
    JO146, a mixture of two diastereomers of a peptidic phosphonate inhibitor for Chlamydial HtrA (CtHtrA), has reported activity against Chlamydia species in both human and koala. In this study we isolated the individual ...
  • Structure-Activity Analysis of Peptidic Chlamydia HtrA Inhibitors 

    Tyndall, Joel; Huston, Wilhelmina; Gamble, Allan; McCaughey, Laura; Marsh, James; Springwald, Alexandra; Mazraani, Rami; Peel, Emma; Hwang, Jimin; Agbowuro, Ayodeji
    Chlamydia trachomatis high temperature requirement A (CtHtrA) is a serine protease that performs proteolytic and chaperone functions in pathogenic Chlamydiae; and is seen as a prospective drug target. This study details ...