Browsing by Degree Name "Bachelor of Biomedical Sciences with Honours"
Now showing items 1-20 of 117
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17α-hydroxylase and the androgen-treated sheep ovary – a model for Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome (PCOS) is the most common cause of infertility in women of reproductive age, with an estimated five to ten percent of women worldwide affected by the endocrine condition. The aetiology of PCOS ... -
A novel genetically encoded voltage indicator for studying motor cortical circuitry
The primary motor cortex (M1) consists of layers that are occupied by distinctive excitatory pyramidal neuron and inhibitory interneuron populations. Neurons within each layer receive inputs from numerous cortical and ... -
A novel strategy to prevent bacterial biofilm formation using methylthioadenosine-nucleosidase inhibitors
Each year there are approximately 2.9 million joint replacement surgeries performed worldwide. Great efforts have been made to reduce infection rates in these replacements in the past and yet these rates have not decreased ... -
A novel technique to investigate coronary microvascular perfusion in diabetes
Diabetes Mellitus (DM)-induced disease of the coronary microvessels contributes to the worldwide increase in cardiovascular morbidity and mortality in diabetic patients. These microvessels are vital to the regulation of ... -
A role for alpha-7 nAChRs at cerebellar synapses
The cerebellum performs a well-known motor control function but accumulating evidence supports its role in cognitive functions. The nicotinic cholinergic system alters cognition through its actions elsewhere in the brain ... -
A search for synthetic lethality between Polo-like Kinase 3 and E- Cadherin
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant condition caused by a mutation in the tumour suppressor gene E-cadherin, (CDH1). It predisposes to a 70% likelihood of developing highly penetrant diffuse ... -
A tale of two fates: the role of histone modifications in establishing bipotentiality
Sex determination and differentiation is an essential process all mammals must undergo to reproduce. This process in mammals is initiated through the development of a bipotential tissue, the urogenital ridge (UGR), which ... -
A Validation Study to Detect Markers of Proliferation Adequacy in the Endometrium
Throughout the human female menstrual cycle, the endometrial lining of the uterus transitions from a non-receptive proliferative state to a receptive secretory state. This transition is required to prepare the endometrium ... -
Adrenergic stimulation of HK-2 proximal tubular cells in hyperglycaemic conditions
One of the most commonly associated complications of Diabetes Mellitus is nephropathy, with one in five diabetics sustaining renal injury over their lives. Renal denervation has been shown to decrease systemic blood pressure ... -
Ageing Astrocytes - Implications for Motoneuron Dysfunction and Sarcopenia
Sarcopenia: The most conspicuous intractable feature of advancing age is the gradual loss of skeletal muscle mass and the resultant loss of strength and mobility, and this is a major driver of morbidity and mortality in ... -
An in vivo investigation into the morphology of whole GnRH neurons
The ability to pass on genetic information through reproduction represents nature’s basic element of existence. Central to the control of reproduction is gonadotropin-releasing hormone (GnRH), a neuropeptide synthesized ... -
Anatomical Characterisation of Prolactin Receptor Expression in the Developing Mouse Brain
Prolactin signalling through the prolactin receptor plays a significant role in many physiological processes. The diverse biological functions attributed to prolactin are largely dependent on the distribution of its receptor. ... -
Association of Interleukin-23 Receptor (IL-23R) gene variants with Gout and Rheumatic Heart Fever (RHF)
Gout is an increasingly common form of inflammatory arthritis caused by the deposition of urate, leading to the formation of monosodium urate (MSU) crystals in joints and other body tissue. This results in subsequent ... -
Bowel Bacteria and Dendritic Cells in Ankylosing Spondylitis
Ankylosing Spondylitis (AS) is chronic inflammatory arthritis of spine and sacroiliac joints with further peripheral manifestations. AS is a relatively common rheumatic disease affecting 0.1- 1.4% of the population. Early ... -
Brain Regions Responding to Endogenous Prolactin during Pregnancy and Lactation
There is an increased incidence of dysfunctional mood disorders postpartum, affecting approximately 10-20% of all women. Postpartum mood disorders can have devastating effects on the mother, and lead to altered relationships ... -
Cardiac function and β-adrenergic receptor responsiveness in the isolated human diabetic myocardium
The prevalence of type 2 diabetic mellitus is closely associated with cardiovascular complications. Diabetic patients with preserved ejection fraction (EF) are at high risk of developing heart failure. Until now, little ... -
Characterisation of Arkadia's RING domain
The attachment of ubiquitin to proteins (ubiquitylation) is a post-translational modification that regulates a diverse range of biological processes, including signal transduction, transcriptional regulation and receptor ... -
Characterising the role of human mTOR in Listeria monocytogenes infection
The pathogenic food bourne bacterium Listeria monocytogenes has the potential to cause gastroenteritis, meningitis and abortion in an infected individual. L. monocytogenes is a facultative intracellular bacterium that ... -
Characterization of Alkyltriphenylphosphonium Cations and Their Interaction with Bacterial Cells
Tuberculosis (TB) is a difficult to treat disease caused by the bacterium Mycobacterium tuberculosis. M. tuberculosis is able to shut down its metabolism in response to diverse environmental cues and enter a stage of ... -
Comparing subpopulations of gonadotropin-releasing hormone (GnRH) neurons with viral mediated cell-filling
Gonadotropin-releasing hormone (GnRH) neurons are the central regulators of reproductive function in all mammals. The cell bodies of GnRH neurons are unique in that they are not confined to a discrete nucleus, but rather ...