Browsing by Degree Name "Bachelor of Biomedical Sciences with Honours"
Now showing items 1-20 of 205
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17α-hydroxylase and the androgen-treated sheep ovary – a model for Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome (PCOS) is the most common cause of infertility in women of reproductive age, with an estimated five to ten percent of women worldwide affected by the endocrine condition. The aetiology of PCOS ... -
A novel genetically encoded voltage indicator for studying motor cortical circuitry
The primary motor cortex (M1) consists of layers that are occupied by distinctive excitatory pyramidal neuron and inhibitory interneuron populations. Neurons within each layer receive inputs from numerous cortical and ... -
A novel leptin receptor mutation causes delayed puberty onset in mice
Reproductive function is tightly controlled by nutritional state due to its high energetic demands. Regulation of fertility according to available energy stores is attained through the integration of metabolic status signals ... -
A novel strategy to prevent bacterial biofilm formation using methylthioadenosine-nucleosidase inhibitors
Each year there are approximately 2.9 million joint replacement surgeries performed worldwide. Great efforts have been made to reduce infection rates in these replacements in the past and yet these rates have not decreased ... -
A novel technique to investigate coronary microvascular perfusion in diabetes
Diabetes Mellitus (DM)-induced disease of the coronary microvessels contributes to the worldwide increase in cardiovascular morbidity and mortality in diabetic patients. These microvessels are vital to the regulation of ... -
A role for alpha-7 nAChRs at cerebellar synapses
The cerebellum performs a well-known motor control function but accumulating evidence supports its role in cognitive functions. The nicotinic cholinergic system alters cognition through its actions elsewhere in the brain ... -
A search for synthetic lethality between Polo-like Kinase 3 and E- Cadherin
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant condition caused by a mutation in the tumour suppressor gene E-cadherin, (CDH1). It predisposes to a 70% likelihood of developing highly penetrant diffuse ... -
A tale of two fates: the role of histone modifications in establishing bipotentiality
Sex determination and differentiation is an essential process all mammals must undergo to reproduce. This process in mammals is initiated through the development of a bipotential tissue, the urogenital ridge (UGR), which ... -
A Validation Study to Detect Markers of Proliferation Adequacy in the Endometrium
Throughout the human female menstrual cycle, the endometrial lining of the uterus transitions from a non-receptive proliferative state to a receptive secretory state. This transition is required to prepare the endometrium ... -
Adolescent autonomy in medical decision making
Normally in the health profession there is a requirement to gain valid consent from patients before treatment can be given. This respect for patient autonomy has become a cornerstone of modern medical practice, however not ... -
Adrenergic stimulation of HK-2 proximal tubular cells in hyperglycaemic conditions
One of the most commonly associated complications of Diabetes Mellitus is nephropathy, with one in five diabetics sustaining renal injury over their lives. Renal denervation has been shown to decrease systemic blood pressure ... -
ADSC-EVs and Macrophage Polarization in Fat Grafting for Breast Reconstruction
Breast Cancer is the most commonly diagnosed cancer among women in New Zealand, with an estimated 3000 women diagnosed in New Zealand every year. The most common form of treatment is surgery, and following treatment, the ... -
Ageing Astrocytes - Implications for Motoneuron Dysfunction and Sarcopenia
Sarcopenia: The most conspicuous intractable feature of advancing age is the gradual loss of skeletal muscle mass and the resultant loss of strength and mobility, and this is a major driver of morbidity and mortality in ... -
An in vivo investigation into the morphology of whole GnRH neurons
The ability to pass on genetic information through reproduction represents nature’s basic element of existence. Central to the control of reproduction is gonadotropin-releasing hormone (GnRH), a neuropeptide synthesized ... -
Anatomical Characterisation of Prolactin Receptor Expression in the Developing Mouse Brain
Prolactin signalling through the prolactin receptor plays a significant role in many physiological processes. The diverse biological functions attributed to prolactin are largely dependent on the distribution of its receptor. ... -
Arterial Hypertension. Consume Carbon Monoxide?
Epithelial sodium channels (ENaC) are generally responsible for the passive movement of sodium ions through the apical cell membrane of salt absorbing epithelia. Canonical ENaC is composed of three homologous subunits, ... -
Aspirin’s role in preventing E-cadherin cleavage by the carcinogenic Bacteroides fragilis toxin
Carriage of enterotoxigenic Bacteroides fragilis (ETBF) in the colonic mucosa is associated with increased risk of pre-cancerous lesions. Antibiotics will not selectively eradicate these bacteria, but toxin-mediated host ... -
Assessing the efficacy of a fluorescent model of the ovarian reserve in mice
In mammalian females, germ cells proliferate exclusively in development resulting in a finite number of oocytes at birth which are kept in a dormant state within primordial follicles. The ovarian reserve (OR) is the ... -
Assessing the translational potential of oxytocin receptor blockade as a novel therapy for cardiac sympathetic activation following acute myocardial infarction
Abnormal elevation of cardiac sympathetic nerve activity (cSNA) is a major contributor to the high mortality rate associated with acute myocardial infarction (MI). Increase in cSNA results in the propagation of ventricular ... -
Association of Interleukin-23 Receptor (IL-23R) gene variants with Gout and Rheumatic Heart Fever (RHF)
Gout is an increasingly common form of inflammatory arthritis caused by the deposition of urate, leading to the formation of monosodium urate (MSU) crystals in joints and other body tissue. This results in subsequent ...