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Functional Analysis of Disease-Associated 3’ UTR Variants: the CXCL12β 3’ UTR G801A Polymorphism
In recent years, the previously neglected 3’ untranslated region (UTR) has gained recognition as a critical region in the regulation of gene expression. Numerous studies have been conducted on disease-associated 3’ UTR ...
The structure of the mucosal folds within the pancreaticobiliary junction
BACKGROUND: This investigation concerns a structure within the pancreaticoduodenal region of the body, known as the pancreaticobiliary junction (PBJ), which is formed from the convergence of the terminal common bile and ...
Reading the Bones: A Taphonomic Analysis of Lapita Mortuary Practices
People carrying the Lapita culture, which first appeared in the Bismarck archipelago c. 3300 BP, were the first colonists of Remote Oceania. While over 200 Lapita sites have been identified throughout the Pacific, very few ...
Public Theology, Core Values and Domestic Violence in Samoan Society
The purpose of this research is to formulate a theologically coherent perspective on the complex social and moral questions facing contemporary Samoan society. It does so by constructing a contextual Samoan public theology, ...
Agmatine and age-related cognitive decline
Declined learning and memory ability is common in aged individuals. Such age-related cognitive decline is associated with the dysfunction of the prefrontal cortex, hippocampus and its adjacent entorhinal, perirhinal and ...
Effect of aging on long-term potentiation-induced gene expression profiles in the hippocampus
Aging is characterized by an increased risk of cognitive deficits. It was shown using rodents that aging is associated with a significant reduction in the function of hippocampus, the brain structure important in forming ...
An evidence-based reappraisal of human surface anatomy
Surface anatomy is routinely taught to medical and anatomy students and is a core component of human anatomy in clinical practice. Accurate surface anatomy and awareness of variations are both essential for safe clinical ...
The arterial supply of the ulnar nerve and cubital tunnel ischaemia
Background: The ulnar nerve is a major nerve in the upper limb and is susceptible to injury, particularly in the region of the cubital tunnel. A suspected mechanism of injury at this site is ischaemia. Whilst this can be ...
Estrogenic modulation of cytokine-signaling pathways within the brain
The gonadal steroid estradiol has widespread and diverse actions within the brain, although many of the cellular mechanisms responsible are unknown. This study extends a previous observation that estradiol can modulate ...
Histamine mediated neuropeptide gene expression in bovine chromaffin cells
The adrenal medulla regulates the acute stress response and is itself controlled through a variety of signals, including neuronal, endocrine and paracrine factors. Additionally, recent literature suggests that adrenal ...