Abstract
Urinary tract infection is one of the most common bacterial infections around the globe, and is an important cause of morbidity, hospitalization, and antibiotic resistance. Urinary tract infection can be upper or lower; lower urinary tract infection refers to infection of the bladder. Uncomplicated lower urinary tract infection is usually a self‐limiting illness. This chapter summarizes the evidence and provides recommendations for the treatment and prevention of uncomplicated lower urinary tract infection in nonpregnant women and in children and men. It also describes the evidence for therapeutic approaches to asymptomatic bacteriuria. Uncomplicated urinary tract infection is associated with a good prognosis in the long term. Several Cochrane systematic reviews of interventions for treatment and prevention of uncomplicated urinary tract infection have been published. In qualitative analysis, women with symptomatic urinary tract infection preferred to avoid antibiotic therapy and would consider nonantibiotic‐based approaches.