Abstract
In this study, we identify requirements for a clinically feasible approach to register histology with radiology data which is suitable for bone tumours. Orthopaedic oncology as the main treatment for bone tumours has benefited from developments in patient-specific surgical systems, equipment, and computation. This surgical technology relies upon clinical radiology. However, the accuracy of identifying tumour margins in clinical radiology is difficult to validate. Three-dimensional registration of histology with pre-operative radiology in a clinical setting could be used to improve the identification of bone tumour margins. Preliminary investigations evaluate four proposed approaches against ranking criteria. The approaches considered are; a double scanning approach, cutting jig guides, a fiducial vector technique, and fast-setting resin fixation. The double scanning approach was identified in canine trials as the most versatile and robust for the variable morphology of bone tumours. Within a clinical workflow, a histology-radiology framework will enable quantitative validation of presurgical image interpretation and planning. This will allow improvements to surgical planning approaches with better-informed resection decisions.