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Cross-tolerance between ethanol and other anaesthetic agents
Conference proceeding   Peer reviewed

Cross-tolerance between ethanol and other anaesthetic agents

J.M. Wood and R. Laverty
Proceedings of the University of Otago Medical School, Vol.56(3), pp.108-109
Proceedings of the University of Otago Medical School
1978
Handle:
https://hdl.handle.net/10523/13193

Abstract

2 propanol alcohol alfadolone alfaxalone butanol chloral hydrate ether halothane pentobarbital anesthesia anesthesia mechanism clinical study cross immunity drug comparison drug tolerance major clinical study therapy
Results of experiments in rats suggest that ethanol produces its depressant effects in the CNS by a mechanism in common with isopropanol, t-butanol, chloral hydrate and ether and that this mechanism is different from that of pentobarbitone, alphaxalone+alphadolone and halothane. This gives further evidence that anaesthetic agents differ in the sites at which they produce their effect.

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