Abstract
In this paper the authors describe studies on cyanide insensitive respiration in Candida albicans. Respiration was inhibited after the addition of KCN to the untreated suspension. Cells incubated with KCN showed, initially, inhibition of respiration similar to that of the controls to which KCN was later added. Respiration of the cyanide incubated cells, however recovered to 70% of the control level within 1 hr and addition of more KCN stimulated respiration further. Salicylhydroxamic acid had no effect on either untreated cells or cells to which KCN had been added later, but it inhibited respiration in cells which had been incubated with KCN and to which further KCN had been added. Similar results were obtained when KCN was replaced by antimycin both in the incubation medium and in the electrode chamber. These results show that there is an alternate oxidase in C. albicans which is unmasked by either KCN or antimycin.