Failure of propranolol to alter changes in collagen content of the heart induced by thyroxine in the rat

R. McChesney; A. Goulding

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Failure of propranolol to alter changes in collagen content of the heart induced by thyroxine in the rat

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Failure of propranolol to alter changes in collagen content of the heart induced by thyroxine in the rat

R. McChesney and A. Goulding

Proceedings of the University of Otago Medical School, Vol.54(1), pp.23-24

Proceedings of the University of Otago Medical School

1976

Handle:

https://hdl.handle.net/10523/13086

Abstract

beta adrenergic receptor blocking agent

collagen

hydroxyproline

propranolol

thyroxine

heart

heart size

heart ventricle hypertrophy

hyperthyroidism

rat

subcutaneous drug administration

theoretical study

Since β blockade has been used clinically to treat cardiovascular manifestations of thyrotoxicosis the effect of propranolol on the collagen content of the heart was studied in rats given amounts of thyroxine (T2) sufficient to induce hyperthyroidism. It is concluded that although an increase in collagen content does contribute to the cardiac hypertrophy induced by T4 the increase in noncollagenous tissue is relatively greater. Propranolol does not alter these responses in hyperthyroidism.

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Record Identifier: 9926479217201891
Title: Failure of propranolol to alter changes in collagen content of the heart induced by thyroxine in the rat
Creators: R. McChesney
A. Goulding
Publication Details: Proceedings of the University of Otago Medical School, Vol.54(1), pp.23-24
Academic Unit: Otago Medical School Research Society
Publisher: Otago Medical School Research Society
Date published ; e-published: 1976
Date copyright: 1976
Comment: Abstract presented at Otago Medical Research Society meeting. There is no published article available. If abstract text is available, it will be included in this record. Abstract presented at Otago Medical Research Society meeting. There is no published article available. If abstract text is digitally available, it will be included in this record. This item is available in holdings at University of Otago Libraries. See https://otago.primo.exlibrisgroup.com/permalink/64OTAGO_INST/qef3lj/alma9911647701891 for more information.
Language: English
Resource Type; Subtype: Conference proceeding

Failure of propranolol to alter changes in collagen content of the heart induced by thyroxine in the rat

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