Abstract
Recent neurophysiologic evidence has suggested that peripheral nerves may be abnormal in multiple sclerosis (MS), a disease traditionally considered to have purely central nervous system pathology. Sural nerve biopsies were undertaken in 10 patients with unequivocal evidence of MS to determine whether the reported neurophysiologic findings have a morphologic correlate. The results suggest an abnormality of peripheral nerve fibers in multiple sclerosis, mainly consisting in an abnormal intranodular length. In 1 nerve, there was some demyelination.