Sign in
Back
Prevention by dibutyryl cyclic AMP of denervation induced fall in muscle fibre resting potential
Conference proceeding   Peer reviewed

Prevention by dibutyryl cyclic AMP of denervation induced fall in muscle fibre resting potential

J.J. Bray, M.J. Hawken and J.I. Hubbard
Proceedings of the University of Otago Medical School, Vol.52(2), pp.19-20
Proceedings of the University of Otago Medical School
1974
Handle:
https://hdl.handle.net/10523/13017

Abstract

adenylate cyclase adrenalin bucladesine cyclic AMP noradrenalin theophylline action potential denervation diaphragm in vitro study membrane potential muscle muscle cell muscle fiber membrane pharmacology rat theoretical study
The denervation induced fall in RMP close to the site of nerve section was reduced in the presence of 10-14M db cyclic AMP and was prevented altogether by 2.5 x 10-14M db cyclic AMP strongly supporting the hypothesis that the adenyl cyclase system was concerned in the trophic action. Cyclic AMP had no effect, presumably because the drug could not penetrate muscle fibre membranes.

Metrics

23 Record Views

Details

Usage Policy

Usage details for all content viewed and downloaded in this site are shared with IRUS-UK (Institutional Repository Usage Statistics UK). Cookies are used to remember your decision. Click Accept to accept usage details sharing and the cookies.

Learn more