Sulphamethoxazole and trimethoprim estimation by high performance liquid chromatography

D.G. Ferry; E.G. McQueen; M.T.W. Hearn

Back

Sulphamethoxazole and trimethoprim estimation by high performance liquid chromatography

Conference proceeding

Peer reviewed

Sulphamethoxazole and trimethoprim estimation by high performance liquid chromatography

D.G. Ferry, E.G. McQueen and M.T.W. Hearn

Proceedings of the University of Otago Medical School, Vol.56(2), pp.46-48

Proceedings of the University of Otago Medical School

1978

Handle:

https://hdl.handle.net/10523/13162

Abstract

cotrimoxazole

n4 acetylsulfamethoxazole

sulfadimethoxine

sulfamethoxazole

trimethoprim

drug blood level

drug determination

drug urine level

high performance liquid chromatography

liquid chromatography

methodology

plasma

serum

theoretical study

urine

Sulphamethoxazole and trimethoprim are the active antibacterial agents in co-trimoxazole preparations. The standard assay procedures for sulphamethoxazole and trimethoprim involve complex spectrophotometric and spectrofluorimetric determinations respectively. The trimethoprim procedure in particular is both time consuming and laborious. The method described in the present paper based on hydrophilic ion-pairing, reversed-phase, high performance liquid chromatography (HPLC) permits the estimation of trimethoprim, sulphamethoxazole and its principal metabolite N4-acetylsulphamethoxazole.

Metrics

30 Record Views

Details

Record Identifier: 9926479995701891
Title: Sulphamethoxazole and trimethoprim estimation by high performance liquid chromatography
Creators: D.G. Ferry
E.G. McQueen
M.T.W. Hearn
Publication Details: Proceedings of the University of Otago Medical School, Vol.56(2), pp.46-48
Academic Unit: Otago Medical School Research Society
Publisher: Otago Medical School Research Society
Date published ; e-published: 1978
Date copyright: 1978
Comment: Abstract presented at Otago Medical Research Society meeting. There is no published article available. If abstract text is digitally available, it will be included in this record. This item is available in holdings at University of Otago Libraries. See https://otago.primo.exlibrisgroup.com/permalink/64OTAGO_INST/qef3lj/alma9911647701891 for more information.
Language: English
Resource Type; Subtype: Conference proceeding

Sulphamethoxazole and trimethoprim estimation by high performance liquid chromatography

Abstract

Related links

Metrics

Details

Usage Policy