Abstract
Purpose: Poorly water-soluble drugs often show dissolution rate limited bioavailability. The aim of this study was to investigate the manufacture of pharmaceutical solid dispersions made by solvent change co-precipitation, as a possible method of improving drug dissolution. […]
Conclusions: The work described in this thesis has demonstrated that in-vitro improvement in dissolution of the drug GWX, can be achieved by formulating it as a fairly stable coprecipitate with HPMCP. The advantages with respect to dissolution seen with high HPMCP:drug ratio co-precipitates, may be offset by cost, possible toxicological issues, and mechanical properties less suitable for handling and/or comminution, due to the high polymer loading. Co-precipitation in the manner used, may therefore be more suitable for high potency (low dose) drugs.