Abstract
The thesis investigates the role of phase I and phase II enzymes in chemoprevention and chemotherapy of cancer. Green, black and herbal teas were chosen to assess the former aspect while a metabolic study of DACA was selected to test the latter. Bioactivation of procarcinogens, detoxification of ultimate carcinogens and biotransformation of chemotherapeutic agents are carried out mainly by drug-metabolizing enzymes. […]
In brief, the present study was able to provide evidence of (a) an association of CYP, UGT and/or GST enzyme activity changes with the anticancer effect of green and herbal teas and (b) mediation of CYP3A in the biotransformation of DACA.