Abstract
This thesis aimed to explore the feasibility and safety of a novel High-Density Transcranial Grey Noise stimulation technique in the treatment of Major Depressive Disorder. This non-invasive therapy is based on a new type of random noise stimulation that is specifically designed to normalise the aberrant inter- and intra-network connectivity observed in depression. This was a double-blinded, sham-controlled, delayed-start trial. Seven patients were recruited and randomise to receive either six weeks of continuous treatment or three weeks of sham treatment followed by three weeks of active stimulation. Electroencephalogram and clinical measures were used to measure the potential effects of this therapy. The data from this trial indicated that this technique could influence the direction and magnitude of pathological EEG signals observed in depression and that these changes positively trend with clinical outcomes. Given that current therapies for depression have plateaued in effectiveness, these findings may hold important implications for the way depression is managed clinically.