Abstract
Using in situ hybridization, we show that the expression of the immediate-early gene,
nur-77, increases rapidly and transiently in hippocampal neurons following activation of muscarinic and
N-methyl-
d-aspartate receptors and after hippocampal long-term potentiation (LTP). On the basis of these results we hypothesize that
nur-77 may coordinate with other transcription factors to initiate subsequent changes in hippocampal gene expression associated with plasticity-related activation of
N-methyl-
d-aspartate and muscarinic receptors.