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Acute liver failure secondary to therapeutic paracetamol dosing in an extremely preterm neonate
Journal article   Peer reviewed

Acute liver failure secondary to therapeutic paracetamol dosing in an extremely preterm neonate

Krishna Raghu and Mary Judith Berry
BMJ case reports, Vol.15(5), p.e245406
06/05/2022
DOI: https://doi.org/10.1136/bcr-2021-245406
Handle:
https://hdl.handle.net/10523/38005

Abstract

Acetaminophen - therapeutic use Ductus Arteriosus, Patent Humans Ibuprofen - therapeutic use Infant Infant, Extremely Premature Infant, Newborn Liver Failure, Acute - chemically induced Liver Failure, Acute - drug therapy Male
We report the first case of standard therapeutic dose paracetamol for patent ductus arteriosus closure causing acute liver failure in an extremely preterm infant. After 5 days of treatment, he presented with jaundice, acute severe hepatitis and coagulopathy. Treatment with N-acetyl cysteine resulted in full recovery.

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