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An iron-oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase
Journal article   Open access   Peer reviewed

An iron-oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase

E. P. Tchesnokov, A. S. Faponle, C. G. Davies, M. G. Quesne, R. Turner, M. Fellner, R. J. Souness, S. M. Wilbanks, S. P. de Visser and G. N. L. Jameson
Chemical communications (Cambridge, England), Vol.52(57), pp.8814-8817
01/01/2016
DOI: https://doi.org/10.1039/c6cc03904a
Handle:
https://hdl.handle.net/10523/29432

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorption maxima at 500 and 640 nm.
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https://doi.org/10.1039/c6cc03904aView
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