Abstract
leaves have traditionally been utilized for relieving body aches, headaches and fever. Based on its uses, the present study was designed to investigate the antinociceptive, antipyretic and anti-edematogenic activities from
leaves' methanol extract (PBME) in Wister rats.
The thermal (hot plate) and chemical (acetic acid-induced writhing and formalin test) models for antinociceptive effects, and the Brewer's yeast induced hyperthermia test for antipyretic action and rat paw edema by carrageenan for anti-edematogenic activity, were applied for PBME at different dose levels. The acute toxicity of PBME through the oral route was performed to determine the lethal dose.
PBME significantly and dose-dependently reduced pyrexia and diminished edema volume, which depicted its antipyretic and anti-edematogenic effects respectively. The inhibition of writhing reflex, increased reaction latency and reduced frequency of licking indicated that PBME has significant dose-dependent antinociceptive activity.
methanol extract at 4000 mg/kg shows no sign of toxicity, which is a considerable, good margin of safety.
The study illustrated the antipyretic, antinociceptive and anti-inflammatory potential of
leaf extract with a safety margin, and validated its traditional use to alleviate fever, pain, and inflammation.