Association of diabetes and breast cancer characteristics at diagnosis

Chunhuan Lao; Jason Gurney; James Stanley; Jeremy Krebs; Ineke Meredith; Ian Campbell; Andrea Teng; Dianne Sika-Paotonu; Jonathan Koea; Ross Lawrenson

doi:10.1007/s10552-022-01654-y

Association of diabetes and breast cancer characteristics at diagnosis

Chunhuan Lao, Jason Gurney, James Stanley, Jeremy Krebs, Ineke Meredith, Ian Campbell, Andrea Teng, Dianne Sika-Paotonu, Jonathan Koea Ross Lawrenson

Cancer causes & control, Vol.34(2), pp.103-111

21/11/2022

: https://doi.org/10.1007/s10552-022-01654-y

https://hdl.handle.net/10523/18907

Breast cancer

Cancer stage

Diabetes

Metformin

Screening

Subtype

Cancer and Chronic Conditions (C3) Collection

C3: Comorbidity and multimorbidity

C3: Cancer and diabetes co-occurrence

Purpose: This study aims to examine the association of diabetes and breast cancer characteristics at diagnosis in Aotearoa/New Zealand. Methods: Patients diagnosed with invasive breast cancer between 2005 and 2020 were identified from the National Breast Cancer Register. Logistic regression modeling was used to estimate the adjusted odds ratio (OR) of having stage III-IV cancer and the OR of having stage IV cancer for women with diabetes compared to those without diabetes. The adjusted OR of having screen-detected breast cancers for patients aged 45-69 years with diabetes compared to patients without diabetes was estimated. Results: 26,968 women were diagnosed with breast cancer, with 3,137 (11.6%) patients having diabetes at the time of cancer diagnosis. The probability of co-occurrence of diabetes and breast cancer increased with time. Māori, Pacific and Asian women were more likely to have diabetes than European/Others. The probability of having diabetes also increased with age. For patients with diabetes, the probability of being diagnosed with stage III-IV cancer and stage IV cancer was higher than for patients without diabetes (OR 1.14, 95% CI 1.03-1.27; and 1.17, 95% CI 1.00-1.38). Women aged 45-69 years with diabetes were more likely to have screen-detected cancer than those without diabetes (OR 1.13, 95% CI 1.02-1.26). Conclusions: The co-occurrence of diabetes and breast cancer is becoming more common. Overall there is a small but significant adverse impact of having advanced disease for women with diabetes that is found at the time of breast cancer diagnosis, and this may contribute to other inequities that occur in the treatment pathway that may impact on patient outcomes.

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url

https://rdcu.be/d7ReE

Published (Version of record)Free to read via Springer Nature SharedIt Initiative,

: 9926495150901891
: Association of diabetes and breast cancer characteristics at diagnosis
: Chunhuan Lao
Jason Gurney
James Stanley
Jeremy Krebs
Ineke Meredith
Ian Campbell
Andrea Teng
Dianne Sika-Paotonu
Jonathan Koea
Ross Lawrenson
: Cancer causes & control, Vol.34(2), pp.103-111
: Public Health (UOW); Pathology and Molecular Medicine (UOW); Medicine (UOW)
: Springer Nature
: The growing crisis of diabetes and cancer co-occurrence, 21/068, Health Research Council of New Zealand (New Zealand, Auckland) - HRC
: 21/11/2022
: Copyright © Springer Nature 2022. All rights reserved. This work was first published in Cancer Causes & Control (Springer Nature). The open access link to the subscription article is provided under the Springer Nature SharedIt Content-Sharing Initiative (https://www.springernature.com/gp/researchers/sharedit) making the view-only full-text article freely and legally accessible to anyone for research purposes and private study via the link: https://rdcu.be/d7ReE.
: English
: Journal article