Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review

Alexandra M Zaborowski; Ahmed Abdile; Michel Adamina; Felix Aigner; Laura d'Allens; Caterina Allmer; Andrea Álvarez; Rocio Anula; Mihailo Andric; Sam Atallah; Simon Bach; Miklosh Bala; Marie Barussaud; Augustinas Bausys; Brendan Bebington; Andrew Beggs; Felipe Bellolio; Melissa-Rose Bennett; Anton Berdinskikh; Vicki Bevan; Sebastiano Biondo; Gabriele Bislenghi; Marc Bludau; Adam Boutall; Nelleke Brouwer; Carl Brown; Christiane Bruns; Daniel D Buchanan; Pamela Buchwald; Jacobus W A Burger; Nikita Burlov; Michela Campanelli; Maylis Capdepont; Michele Carvello; Hwee-Hoon Chew; Dimitri Christoforidis; David Clark; Marta Climent; Kyle G Cologne; Tomas Contreras; Roland Croner; Ian R Daniels; Giovanni Dapri; Justin Davies; Paolo Delrio; Quentin Denost; Michael Deutsch; Andre Dias; André D'Hoore; Evgeniy Drozdov; Daniel Duek; Malcolm Dunlop; Adam Dziki; Aleksandra Edmundson; Sergey Efetov; Alaa El-Hussuna; Brodie Elliot; Sameh Emile; Eloy Espin; Martyn Evans; Seraina Faes; Omar Faiz; Fergal Fleming; Caterina Foppa; George Fowler; Matteo Frasson; Nuno Figueiredo; Tim Forgan; Frank Frizelle; Shamil Gadaev; Jose Gellona; Tamara Glyn; Jianping Gong; Barisic Goran; Emma Greenwood; Marianne G Guren; Stephanie Guillon; Ida Gutlic; Dieter Hahnloser; Heather Hampel; Ann Hanly; Hirotoshi Hasegawa; Lene Hjerrild Iversen; Andrew Hill; James Hill; Jiri Hoch; Michael Hoffmeister; Roel Hompes; Luis Hurtado; Fabiano Iaquinandi; Ugne Imbrasaite; Rumana Islam; Mehrenah Dorna Jafari; Yukihide Kanemitsu; Aleksei Karachun; Ahmer A Karimuddin; Deborah S Keller; Justin Kelly; Rory Kennelly; Gleb Khrykov; Peter Kocian; Cherry Koh; Neils Kok; Katrina A Knight; Joep Knol; Christos Kontovounisios; Hartwig Korner; Zoran Krivokapic; Irmgard Kronberger; Hidde Maarten Kroon; Marius Kryzauskas; Said Kural; Miranda Kusters; Zaher Lakkis; Timur Lankov; Dave Larson; György Lázár; Kai-Yin Lee; Suk Hwan Lee; Jérémie H Lefèvre; Anna Lepisto; Christopher Lieu; Lynette Loi; Craig Lynch; Helene Maillou-Martinaud; Annalisa Maroli; Sean Martin; Anna Martling; Klaus E Matzel; Julio Mayol; Frank McDermott; Guillaume Meurette; Monica Millan; Martin Mitteregger; Andrei Moiseenko; John R T Monson; Stefan Morarasu; Konosuke Moritani; Gabriela Möslein; Martino Munini; Caio Nahas; Sergio Nahas; Ionut Negoi; Anastasia Novikova; Misael Ocares; Koji Okabayashi; Alexandra Olkina; Luis Oñate-Ocaña; Jaime Otero; Cihan Ozen; Ugo Pace; Guilherme Pagin São Julião; Lidiia Panaiotti; Yves Panis; Demetris Papamichael; Jason Park; Swati Patel; Juan Carlos Patrón Uriburu; Miguel Pera; Rodrigo O Perez; Alexei Petrov; Frank Pfeffer; P Terry Phang; Tomas Poskus; Heather Pringle; David Proud; Ivana Raguz; Nuno Rama; Shahnawaz Rasheed; Manoj J Raval; Daniela Rega; Christoph Reissfelder; Juan Carlos Reyes Meneses; Frederic Ris; Stefan Riss; Homero Rodriguez-Zentner; Campbell S Roxburgh; Avanish Saklani; Andrea Jiménez Salido; Tarik Sammour; Deborah Saraste; Martin Schneider; Ryo Seishima; Aleksandar Sekulic; Toni Seppala; Kieran Sheahan; Rebecca Shine; Alexandra Shlomina; Guiseppe S Sica; Tongplaew Singnomklao; Leandro Siragusa; Neil Smart; Alejandro Solis; Antonino Spinelli; Roxane D Staiger; Michael J Stamos; Scott Steele; Michael Sunderland; Ker-Kan Tan; Pieter J Tanis; Paris Tekkis; Biniam Teklay; Sabrina Tengku; Marta Jiménez-Toscano; Petr Tsarkov; Matthias Turina; Alexis Ulrich; Bruna B Vailati; Meike van Harten; Cornelis Verhoef; Satish Warrier; Steve Wexner; Hans de Wilt; Benjamin A Weinberg; Cameron Wells; Albert Wolthuis; Evangelos Xynos; Nancy You; Alexander Zakharenko; Justino Zeballos; Des C Winter; REACCT Collaborative

doi:10.1001/jamasurg.2021.2380

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Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review

Journal article

Peer reviewed

Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review

Alexandra M Zaborowski, Ahmed Abdile, Michel Adamina, Felix Aigner, Laura d'Allens, Caterina Allmer, Andrea Álvarez, Rocio Anula, Mihailo Andric, Sam Atallah, …

JAMA surgery, Vol.156(9), pp.865-874

01/09/2021

DOI: https://doi.org/10.1001/jamasurg.2021.2380

Handle:

https://hdl.handle.net/10523/18186

Abstract

Adult

Age of Onset

Colorectal Neoplasms - epidemiology

Colorectal Neoplasms - pathology

Humans

Incidence

Middle Aged

Risk Factors

The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer. Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts. The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.

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Record Identifier: 9926494828501891
Title: Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review
Creators: Alexandra M Zaborowski
Ahmed Abdile
Michel Adamina
Felix Aigner
Laura d'Allens
Caterina Allmer
Andrea Álvarez
Rocio Anula
Mihailo Andric
Sam Atallah
Simon Bach
Miklosh Bala
Marie Barussaud
Augustinas Bausys
Brendan Bebington
Andrew Beggs
Felipe Bellolio
Melissa-Rose Bennett
Anton Berdinskikh
Vicki Bevan
Sebastiano Biondo
Gabriele Bislenghi
Marc Bludau
Adam Boutall
Nelleke Brouwer
Carl Brown
Christiane Bruns
Daniel D Buchanan
Pamela Buchwald
Jacobus W A Burger
Nikita Burlov
Michela Campanelli
Maylis Capdepont
Michele Carvello
Hwee-Hoon Chew
Dimitri Christoforidis
David Clark
Marta Climent
Kyle G Cologne
Tomas Contreras
Roland Croner
Ian R Daniels
Giovanni Dapri
Justin Davies
Paolo Delrio
Quentin Denost
Michael Deutsch
Andre Dias
André D'Hoore
Evgeniy Drozdov
Daniel Duek
Malcolm Dunlop
Adam Dziki
Aleksandra Edmundson
Sergey Efetov
Alaa El-Hussuna
Brodie Elliot
Sameh Emile
Eloy Espin
Martyn Evans
Seraina Faes
Omar Faiz
Fergal Fleming
Caterina Foppa
George Fowler
Matteo Frasson
Nuno Figueiredo
Tim Forgan
Frank Frizelle
Shamil Gadaev
Jose Gellona
Tamara Glyn
Jianping Gong
Barisic Goran
Emma Greenwood
Marianne G Guren
Stephanie Guillon
Ida Gutlic
Dieter Hahnloser
Heather Hampel
Ann Hanly
Hirotoshi Hasegawa
Lene Hjerrild Iversen
Andrew Hill
James Hill
Jiri Hoch
Michael Hoffmeister
Roel Hompes
Luis Hurtado
Fabiano Iaquinandi
Ugne Imbrasaite
Rumana Islam
Mehrenah Dorna Jafari
Yukihide Kanemitsu
Aleksei Karachun
Ahmer A Karimuddin
Deborah S Keller
Justin Kelly
Rory Kennelly
Gleb Khrykov
Peter Kocian
Cherry Koh
Neils Kok
Katrina A Knight
Joep Knol
Christos Kontovounisios
Hartwig Korner
Zoran Krivokapic
Irmgard Kronberger
Hidde Maarten Kroon
Marius Kryzauskas
Said Kural
Miranda Kusters
Zaher Lakkis
Timur Lankov
Dave Larson
György Lázár
Kai-Yin Lee
Suk Hwan Lee
Jérémie H Lefèvre
Anna Lepisto
Christopher Lieu
Lynette Loi
Craig Lynch
Helene Maillou-Martinaud
Annalisa Maroli
Sean Martin
Anna Martling
Klaus E Matzel
Julio Mayol
Frank McDermott
Guillaume Meurette
Monica Millan
Martin Mitteregger
Andrei Moiseenko
John R T Monson
Stefan Morarasu
Konosuke Moritani
Gabriela Möslein
Martino Munini
Caio Nahas
Sergio Nahas
Ionut Negoi
Anastasia Novikova
Misael Ocares
Koji Okabayashi
Alexandra Olkina
Luis Oñate-Ocaña
Jaime Otero
Cihan Ozen
Ugo Pace
Guilherme Pagin São Julião
Lidiia Panaiotti
Yves Panis
Demetris Papamichael
Jason Park
Swati Patel
Juan Carlos Patrón Uriburu
Miguel Pera
Rodrigo O Perez
Alexei Petrov
Frank Pfeffer
P Terry Phang
Tomas Poskus
Heather Pringle
David Proud
Ivana Raguz
Nuno Rama
Shahnawaz Rasheed
Manoj J Raval
Daniela Rega
Christoph Reissfelder
Juan Carlos Reyes Meneses
Frederic Ris
Stefan Riss
Homero Rodriguez-Zentner
Campbell S Roxburgh
Avanish Saklani
Andrea Jiménez Salido
Tarik Sammour
Deborah Saraste
Martin Schneider
Ryo Seishima
Aleksandar Sekulic
Toni Seppala
Kieran Sheahan
Rebecca Shine
Alexandra Shlomina
Guiseppe S Sica
Tongplaew Singnomklao
Leandro Siragusa
Neil Smart
Alejandro Solis
Antonino Spinelli
Roxane D Staiger
Michael J Stamos
Scott Steele
Michael Sunderland
Ker-Kan Tan
Pieter J Tanis
Paris Tekkis
Biniam Teklay
Sabrina Tengku
Marta Jiménez-Toscano
Petr Tsarkov
Matthias Turina
Alexis Ulrich
Bruna B Vailati
Meike van Harten
Cornelis Verhoef
Satish Warrier
Steve Wexner
Hans de Wilt
Benjamin A Weinberg
Cameron Wells
Albert Wolthuis
Evangelos Xynos
Nancy You
Alexander Zakharenko
Justino Zeballos
Des C Winter
REACCT Collaborative
Publication Details: JAMA surgery, Vol.156(9), pp.865-874
Academic Unit: Surgery and Critical Care (UOC)
Grant note: 12076 / Cancer Research UK MC_PC_U127527198 / Medical Research Council 25354 / Cancer Research UK R01 CA229259 / NCI NIH HHS MC_UU_00007/1 / Medical Research Council MC_U127527198 / Medical Research Council 18927 / Cancer Research UK
Date published ; e-published: 01/09/2021
Language: English
Resource Type ; Subtype: Journal article

Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review

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