Childhood Acute Lymphoblastic Leukemia and Indicators of Early Immune Stimulation: A Childhood Leukemia International Consortium Study

Jeremie Rudant; Tracy Lightfoot; Kevin Y. Urayama; Eleni Petridou; John D. Dockerty; Corrado Magnani; Elizabeth Milne; Logan G. Spector; Lesley J. Ashton; Nikolaos Dessypris; Alice Y. Kang; Margaret Miller; Roberto Rondelli; Jill Simpson; Eftichia Stiakaki; Laurent Orsi; Eve Roman; Catherine Metayer; Claire Infante-Rivard; Jacqueline Clavel

doi:10.1093/aje/kwu298

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Childhood Acute Lymphoblastic Leukemia and Indicators of Early Immune Stimulation: A Childhood Leukemia International Consortium Study

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Childhood Acute Lymphoblastic Leukemia and Indicators of Early Immune Stimulation: A Childhood Leukemia International Consortium Study

Jeremie Rudant, Tracy Lightfoot, Kevin Y. Urayama, Eleni Petridou, John D. Dockerty, Corrado Magnani, Elizabeth Milne, Logan G. Spector, Lesley J. Ashton, Nikolaos Dessypris, …

American journal of epidemiology, Vol.181(8), pp.549-562

15/04/2015

DOI: https://doi.org/10.1093/aje/kwu298

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https://hdl.handle.net/10523/30636

Abstract

Life Sciences & Biomedicine

Public, Environmental & Occupational Health

Science & Technology

The associations between childhood acute lymphoblastic leukemia (ALL) and several proxies of early stimulation of the immune system, that is, day-care center attendance, birth order, maternally reported common infections in infancy, and breastfeeding, were investigated by using data from 11 case-control studies participating in the Childhood Leukemia International Consortium (enrollment period: 1980-2010). The sample included 7,399 ALL cases and 11,181 controls aged 2-14 years. The data were collected by questionnaires administered to the parents. Pooled odds ratios and 95% confidence intervals were estimated by unconditional logistic regression adjusted for age, sex, study, maternal education, and maternal age. Day-care center attendance in the first year of life was associated with a reduced risk of ALL (odds ratio = 0.77, 95% confidence interval: 0.71, 0.84), with a marked inverse trend with earlier age at start (P < 0.0001). An inverse association was also observed with breastfeeding duration of 6 months or more (odds ratio = 0.86, 95% confidence interval: 0.79, 0.94). No significant relationship with a history of common infections in infancy was observed even though the odds ratio was less than 1 for more than 3 infections. The findings of this large pooled analysis reinforce the hypothesis that day-care center attendance in infancy and prolonged breastfeeding are associated with a decreased risk of ALL.

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Record Identifier: 9926516591701891
Title: Childhood Acute Lymphoblastic Leukemia and Indicators of Early Immune Stimulation: A Childhood Leukemia International Consortium Study
Creators: Jeremie Rudant
Tracy Lightfoot
Kevin Y. Urayama
Eleni Petridou
John D. Dockerty
Corrado Magnani
Elizabeth Milne
Logan G. Spector
Lesley J. Ashton
Nikolaos Dessypris
Alice Y. Kang
Margaret Miller
Roberto Rondelli
Jill Simpson
Eftichia Stiakaki
Laurent Orsi
Eve Roman
Catherine Metayer
Claire Infante-Rivard
Jacqueline Clavel
Publication Details: American journal of epidemiology, Vol.181(8), pp.549-562
Academic Unit: Public Health (DSM)
Publisher: Oxford Univ Press
Grant note: French Ministere de l'Environnement Cancer Society of New Zealand 2010/097; 2013/151 / United Kingdom Children with Cancer Foundation Ministry for Instruction, University, and Research Fondation Jeanne Liot US National Cancer Institute (Epidemiology and Genomics Research Program) Association pour la Recherche sur le Cancer; Fondation ARC pour la Recherche sur le Cancer; Australian Research Council Children with Cancer Foundation, United Kingdom Canadian Bureau of Chronic Disease Epidemiology A. B. de Lautour Charitable Trust P01 ES018172; R01 ES09137; P42-ES04705 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Italian Association on Research on Cancer RD83451101 / US Environmental Protection Agency; United States Environmental Protection Agency National Health and Research Development Program, Ottawa, Canada Health and Welfare Canada Association pour la Recherche Contre le Cancer; Fondation ARC pour la Recherche sur le Cancer Agence Nationale de la Recherche; Agence Nationale de la Recherche (ANR) R03CA132172 / US National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Otago Medical Research Foundation Fondation de France R01CA049450 (E14); R01CA048051 (E15) / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA ALSF 20140461 / Alex's Lemonade Stand Foundation Association Cent pour Sang la Vie Ministry of Health P01 ES018172; R13 ES021145-01; 1R13 CA174342-01; 1R13 ES024632-01 / US National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) Leukemia Research Fund of Canada Ligue Contre le Cancer du Val de Marne 981141 / Fonds de la Recherche en Sante du Quebec; Fonds de recherche du Quebec (FRQ); Fonds de recherche du Quebec - Sante (FRQS) Ligue Nationale Contre le Cancer; Ligue nationale contre le cancer INSERM; Institut National de la Sante et de la Recherche Medicale (Inserm) Health Research Council of New Zealand New Zealand Lottery Grants Board Otago Medical School (Faculty Bequest Funds) Leukaemia and Lymphoma Research Ministry of Labour, Piedmont Region Children's Cancer Research Fund, Minneapolis, Minnesota MOP 37951 / Medical Research Council of Canada; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 014113; 010735-CERN; RFA0405 / National Cancer Institute of Canada; Canadian Cancer Society (CCS) Canceropole Ile-de-France; Region Ile-de-France Fondation Weisbrem-Berenson Institut National du Cancer; Institut National du Cancer (INCA) France 254539 / Australian National Health and Medical Research Council; National Health & Medical Research Council (NHMRC) of Australia National and Kapodistrian University, Athens, Greece Agence Francaise de Securite Sanitaire des Produits de Sante the Agence Francaise de Securite Sanitaire de l'Environnement et du Travail
Date published ; e-published: 15/04/2015
Language: English
Resource Type ; Subtype: Journal article