Abstract
Background
Attenuation of the inflammatory response in patients undergoing colectomy with modern perioperative care and laparoscopic surgery has been a focus of research in recent years. Despite reported benefits, significant heterogeneity remains with studies including patients undergoing both rectal and colon surgery and including surgery with postoperative complications. Therefore, the aim of the study was to evaluate the inflammatory response in patients undergoing elective colectomy without complications, specifically comparing open and laparoscopic approaches.
Methods
A multicenter prospective study was conducted across four public hospitals in Auckland and Christchurch, New Zealand. Consecutive adults undergoing elective colectomy were included over a 3‐year period. Perioperative blood samples were collected and analysed for the following inflammatory markers: IL‐6, IL‐1β, TNFα, IL‐10, CRP, leucocyte and neutrophil count. Statistical analysis was performed using SPSS statistical software.
Results
A total of 168 colectomy patients without complications were included in the analysis. Patients that underwent laparoscopy had significantly reduced IL‐6, neutrophils and CRP on postoperative day (POD) 1 (p < 0.05) compared to an open approach. IL‐10 and TNFα were significantly reduced on POD 2 (p < 0.05) in laparoscopic patients. Patients with a Body Mass Index (BMI) greater than 30 kg/m2 had significantly higher levels of CRP regardless of operative approach. Statins altered both preoperative and postoperative inflammatory markers.
Conclusion
The postoperative inflammatory response is influenced by surgical approach, perioperative medications, and patient factors. These findings have important implications in the utility of biomarkers in the diagnosis of postoperative surgical complications, in particular in the early diagnosis of anastomotic leak.
A multicenter prospective observational study was conducted of consecutive adults undergoing elective colectomy over a 3‐year period. Inflammatory markers: IL‐6, IL‐1β, TNFα, IL‐10, CRP, leucocyte and neutrophil count were analyzed in the perioperative period. The postoperative inflammatory response is influenced by surgical approach, perioperative medications, and patient factors.