Abstract
Aim
Delayed gastric emptying (GE) has been demonstrated in adults with type 1 diabetes mellitus (T1DM). Little is known about GE in children with T1DM. Most methods to measure GE are invasive, that is, scintigraphy, or are only indirectly related to GE, that is, electrogastrography. Carbon‐13 breath testing is a non‐invasive, very low‐risk procedure that accurately correlates with GE time. This was a pilot study to determine the feasibility of using carbon‐13 breath testing to measure GE in children with T1DM and healthy controls.
Methods
Cases were recruited from children aged 7–15 years presenting to the paediatric diabetic clinic at Christchurch Hospital. Controls were peers of the cases. Children with known gastrointestinal disease were excluded. After an overnight fast, each child ate a standardised pancake labelled with carbon‐13 sodium octanoate. Samples of breath were collected over a 4‐h period. Samples were analysed by mass spectrometry. GE half time (GET1/2) and GE coefficients (GEC) were calculated by linear regression to obtain a measure of GE.
Results
A total of 19 cases and 15 age‐ and gender‐matched controls underwent testing. The mean GEC in the cases was 3.19 (±0.38) and 2.90 (±0.29) in controls (P = 0.03), with an effect size = 0.86. Mean GET1/2 in the cases was 99 (52.1) min and 103 (27.5) in controls (P = 0.8), with an effect size = 0.1.
Conclusion
The study generated results suggesting that a larger study will be worthwhile to investigate the relationship between GE and T1DM.