Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Edith Hofer; Gennady V Roshchupkin; Hieab H H Adams; Maria J Knol; Honghuang Lin; Shuo Li; Habil Zare; Shahzad Ahmad; Nicola J Armstrong; Claudia L Satizabal; Manon Bernard; Joshua C Bis; Nathan A Gillespie; Michelle Luciano; Aniket Mishra; Markus Scholz; Alexander Teumer; Rui Xia; Xueqiu Jian; Thomas H Mosley; Yasaman Saba; Lukas Pirpamer; Stephan Seiler; James T Becker; Owen Carmichael; Jerome I Rotter; Bruce M Psaty; Oscar L Lopez; Najaf Amin; Sven J van der Lee; Qiong Yang; Jayandra J Himali; Pauline Maillard; Alexa S Beiser; Charles DeCarli; Sherif Karama; Lindsay Lewis; Mat Harris; Mark E Bastin; Ian J Deary; A Veronica Witte; Frauke Beyer; Markus Loeffler; Karen A Mather; Peter R Schofield; Anbupalam Thalamuthu; John B Kwok; Margaret J Wright; David Ames; Julian Trollor; Jiyang Jiang; Henry Brodaty; Wei Wen; Meike W Vernooij; Albert Hofman; André G Uitterlinden; Wiro J Niessen; Katharina Wittfeld; Robin Bülow; Uwe Völker; Zdenka Pausova; G Bruce Pike; Sophie Maingault; Fabrice Crivello; Christophe Tzourio; Philippe Amouyel; Bernard Mazoyer; Michael C Neale; Carol E Franz; Michael J Lyons; Matthew S Panizzon; Ole A Andreassen; Anders M Dale; Mark Logue; Katrina L Grasby; Neda Jahanshad; Jodie N Painter; Lucía Colodro-Conde; Janita Bralten; Derrek P Hibar; Penelope A Lind; Fabrizio Pizzagalli; Jason L Stein; Paul M Thompson; Sarah E Medland; Perminder S Sachdev; William S Kremen; Joanna M Wardlaw; Arno Villringer; Cornelia M van Duijn; Hans J Grabe; William T Longstreth, Jr; Myriam Fornage; Tomas Paus; Stephanie Debette; M Arfan Ikram; Helena Schmidt; Reinhold Schmidt; Sudha Seshadri; ENIGMA consortium; Timothy John Anderson

doi:10.1038/s41467-020-18367-y

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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Edith Hofer, Gennady V Roshchupkin, Hieab H H Adams, Maria J Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J Armstrong, Claudia L Satizabal, …

Nature communications, Vol.11(1), pp.4796-4796

22/09/2020

DOI: https://doi.org/10.1038/s41467-020-18367-y

Handle:

https://hdl.handle.net/10523/18324

Abstract

Adult

Aged

Aged, 80 and over

Aging - genetics

Brain

Chromosome Structures

Cognition

Female

Genome-Wide Association Study

Genomics

Humans

Male

Mental Disorders - genetics

Middle Aged

Neurodegenerative Diseases - genetics

Phenotype

Polymorphism, Single Nucleotide

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.

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Record Identifier: 9926495555301891
Title: Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Creators: Edith Hofer
Gennady V Roshchupkin
Hieab H H Adams
Maria J Knol
Honghuang Lin
Shuo Li
Habil Zare
Shahzad Ahmad
Nicola J Armstrong
Claudia L Satizabal
Manon Bernard
Joshua C Bis
Nathan A Gillespie
Michelle Luciano
Aniket Mishra
Markus Scholz
Alexander Teumer
Rui Xia
Xueqiu Jian
Thomas H Mosley
Yasaman Saba
Lukas Pirpamer
Stephan Seiler
James T Becker
Owen Carmichael
Jerome I Rotter
Bruce M Psaty
Oscar L Lopez
Najaf Amin
Sven J van der Lee
Qiong Yang
Jayandra J Himali
Pauline Maillard
Alexa S Beiser
Charles DeCarli
Sherif Karama
Lindsay Lewis
Mat Harris
Mark E Bastin
Ian J Deary
A Veronica Witte
Frauke Beyer
Markus Loeffler
Karen A Mather
Peter R Schofield
Anbupalam Thalamuthu
John B Kwok
Margaret J Wright
David Ames
Julian Trollor
Jiyang Jiang
Henry Brodaty
Wei Wen
Meike W Vernooij
Albert Hofman
André G Uitterlinden
Wiro J Niessen
Katharina Wittfeld
Robin Bülow
Uwe Völker
Zdenka Pausova
G Bruce Pike
Sophie Maingault
Fabrice Crivello
Christophe Tzourio
Philippe Amouyel
Bernard Mazoyer
Michael C Neale
Carol E Franz
Michael J Lyons
Matthew S Panizzon
Ole A Andreassen
Anders M Dale
Mark Logue
Katrina L Grasby
Neda Jahanshad
Jodie N Painter
Lucía Colodro-Conde
Janita Bralten
Derrek P Hibar
Penelope A Lind
Fabrizio Pizzagalli
Jason L Stein
Paul M Thompson
Sarah E Medland
Perminder S Sachdev
William S Kremen
Joanna M Wardlaw
Arno Villringer
Cornelia M van Duijn
Hans J Grabe
William T Longstreth, Jr
Myriam Fornage
Tomas Paus
Stephanie Debette
M Arfan Ikram
Helena Schmidt
Reinhold Schmidt
Sudha Seshadri
ENIGMA consortium
Timothy John Anderson
Publication Details: Nature communications, Vol.11(1), pp.4796-4796
Academic Unit: Medicine (UOC)
Grant note: MR/M013111/1 / Medical Research Council HHSN268201100007C / NHLBI NIH HHS U01 AG049505 / NIA NIH HHS UL1 TR001881 / NCATS NIH HHS TMH109788 / CIHR R01 AG049607 / NIA NIH HHS MC_QA137853 / Medical Research Council R01 HL103612 / NHLBI NIH HHS R01 MH117601 / NIMH NIH HHS HHSN268201100011C / NHLBI NIH HHS R01 MH116147 / NIMH NIH HHS HHSN268201100005C / NHLBI NIH HHS RF1 AG051710 / NIA NIH HHS R01 AG059874 / NIA NIH HHS HHSN268201100010C / NHLBI NIH HHS 8200 / Medical Research Council R01 NS087541 / NINDS NIH HHS U54 EB020403 / NIBIB NIH HHS N02 HL64278 / NHLBI NIH HHS MR/M01311/1 / Medical Research Council R01 AG008122 / NIA NIH HHS HHSN268201500001I / NHLBI NIH HHS G0700704 / Medical Research Council N01HC25195 / NHLBI NIH HHS R01 AG033040 / NIA NIH HHS S10 OD023696 / NIH HHS MC_PC_17228 / Medical Research Council N01HC85081 / NHLBI NIH HHS RF1 AG041915 / NIA NIH HHS MR/R024065/1 / Medical Research Council R01 AG054076 / NIA NIH HHS R01 HL087652 / NHLBI NIH HHS N01HC85086 / NHLBI NIH HHS U01 HL080295 / NHLBI NIH HHS R01 AG022381 / NIA NIH HHS 75N92019D00031 / NHLBI NIH HHS R01 HL120393 / NHLBI NIH HHS R01 AG050595 / NIA NIH HHS N01HC85083 / NHLBI NIH HHS R01 NS017950 / NINDS NIH HHS NRF86678 / CIHR HHSN268201100012C / NHLBI NIH HHS R01 AG033193 / NIA NIH HHS N01HC85080 / NHLBI NIH HHS R01 AG023629 / NIA NIH HHS HHSN268201800001C / NHLBI NIH HHS HHSN268201100006C / NHLBI NIH HHS P30 AG010129 / NIA NIH HHS P41 EB015922 / NIBIB NIH HHS R01 EB015611 / NIBIB NIH HHS HHSN268201200036C / NHLBI NIH HHS RC2 HL102419 / NHLBI NIH HHS R01 AG016495 / NIA NIH HHS N01HC55222 / NHLBI NIH HHS U01 HL130114 / NHLBI NIH HHS HHSN268200800007C / NHLBI NIH HHS N01HC85082 / NHLBI NIH HHS P01 AG026572 / NIA NIH HHS HHSN268201100008C / NHLBI NIH HHS NET54015 / CIHR G0700704/84698 / Medical Research Council G1001401 / Medical Research Council R01 HL105756 / NHLBI NIH HHS G1001245 / Medical Research Council MR/K026992/1 / Medical Research Council BB/F019394/1 / Biotechnology and Biological Sciences Research Council HHSN268201100009C / NHLBI NIH HHS N01HC85079 / NHLBI NIH HHS MR/N027558/1 / Medical Research Council G0701120 / Medical Research Council
Date published ; e-published: 22/09/2020
Language: English
Resource Type ; Subtype: Journal article