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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Journal article   Open access   Peer reviewed

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Hunna J Watson, Zeynep Yilmaz, Laura M Thornton, Christopher Hübel, Jonathan R I Coleman, Héléna A Gaspar, Julien Bryois, Anke Hinney, Virpi M Leppä, Manuel Mattheisen, …
Nature genetics, Vol.51(8), pp.1207-1214
01/08/2019
DOI: https://doi.org/10.1038/s41588-019-0439-2
Handle:
https://hdl.handle.net/10523/27580
Appears in  Christchurch Health and Development Study

Abstract

Adult Anorexia Nervosa - etiology Anorexia Nervosa - genetics Anorexia Nervosa - pathology Body Mass Index Case-Control Studies Female Genetic Predisposition to Disease Genome-Wide Association Study Genomics - methods Humans Male Mental Disorders - complications Mental Disorders - genetics Metabolic Diseases - complications Metabolic Diseases - genetics Phenotype Prognosis Quantitative Trait Loci
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9–4% of women and 0.3% of men2,3,4, with twin-based heritability estimates of 50–60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
url
https://rdcu.be/dXesMView
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