Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Andre Franke; Dermot P. B. McGovern; Jeffrey C. Barrett; Kai Wang; Graham L. Radford-Smith; Tariq Ahmad; Charlie W. Lees; Tobias Balschun; James Lee; Rebecca Roberts; Carl A. Anderson; Joshua C. Bis; Suzanne Bumpstead; David Ellinghaus; Eleonora M. Festen; Michel Georges; Todd Green; Talin Haritunians; Luke Jostins; Anna Latiano; Christopher G. Mathew; Grant W. Montgomery; Natalie J. Prescott; Soumya Raychaudhuri; Jerome I. Rotter; Philip Schumm; Yashoda Sharma; Lisa A. Simms; Kent D. Taylor; David Whiteman; Cisca Wijmenga; Robert N. Baldassano; Murray Barclay; Theodore M. Bayless; Stephan Brand; Carsten Buening; Albert Cohen; Jean-Frederick Colombel; Mario Cottone; Laura Stronati; Ted Denson; Martine De Vos; Renata D'Inca; Marla Dubinsky; Cathryn Edwards; Tim Florin; Denis Franchimont; Richard Gearry; Juergen Glas; Andre Van Gossum; Stephen L. Guthery; Jonas Halfvarson; Hein W. Verspaget; Jean-Pierre Hugot; Amir Karban; Debby Laukens; Ian Lawrance; Marc Lemann; Arie Levine; Cecile Libioulle; Edouard Louis; Craig Mowat; William Newman; Julian Panes; Anne Phillips; Deborah D. Proctor; Miguel Regueiro; Richard Russell; Paul Rutgeerts; Jeremy Sanderson; Miquel Sans; Frank Seibold; A. Hillary Steinhart; Pieter C. F. Stokkers; Leif Torkvist; Gerd Kullak-Ublick; David Wilson; Thomas Walters; Stephan R. Targan; Steven R. Brant; John D. Rioux; Mauro D'Amato; Rinse K. Weersma; Subra Kugathasan; Anne M. Griffiths; John C. Mansfield; Severine Vermeire; Richard H. Duerr; Mark S. Silverberg; Jack Satsangi; Stefan Schreiber; Judy H. Cho; Vito Annese; Hakon Hakonarson; Mark J. Daly; Miles Parkes

doi:10.1038/ng.717

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Andre Franke, Dermot P. B. McGovern, Jeffrey C. Barrett, Kai Wang, Graham L. Radford-Smith, Tariq Ahmad, Charlie W. Lees, Tobias Balschun, James Lee, Rebecca Roberts, …

Nature genetics, Vol.42(12), pp.1118-1125

01/12/2010

: https://doi.org/10.1038/ng.717

https://hdl.handle.net/10523/33580

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 x 10(-8)). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.

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: Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
: Andre Franke
Dermot P. B. McGovern
Jeffrey C. Barrett
Kai Wang
Graham L. Radford-Smith
Tariq Ahmad
Charlie W. Lees
Tobias Balschun
James Lee
Rebecca Roberts
Carl A. Anderson
Joshua C. Bis
Suzanne Bumpstead
David Ellinghaus
Eleonora M. Festen
Michel Georges
Todd Green
Talin Haritunians
Luke Jostins
Anna Latiano
Christopher G. Mathew
Grant W. Montgomery
Natalie J. Prescott
Soumya Raychaudhuri
Jerome I. Rotter
Philip Schumm
Yashoda Sharma
Lisa A. Simms
Kent D. Taylor
David Whiteman
Cisca Wijmenga
Robert N. Baldassano
Murray Barclay
Theodore M. Bayless
Stephan Brand
Carsten Buening
Albert Cohen
Jean-Frederick Colombel
Mario Cottone
Laura Stronati
Ted Denson
Martine De Vos
Renata D'Inca
Marla Dubinsky
Cathryn Edwards
Tim Florin
Denis Franchimont
Richard Gearry
Juergen Glas
Andre Van Gossum
Stephen L. Guthery
Jonas Halfvarson
Hein W. Verspaget
Jean-Pierre Hugot
Amir Karban
Debby Laukens
Ian Lawrance
Marc Lemann
Arie Levine
Cecile Libioulle
Edouard Louis
Craig Mowat
William Newman
Julian Panes
Anne Phillips
Deborah D. Proctor
Miguel Regueiro
Richard Russell
Paul Rutgeerts
Jeremy Sanderson
Miquel Sans
Frank Seibold
A. Hillary Steinhart
Pieter C. F. Stokkers
Leif Torkvist
Gerd Kullak-Ublick
David Wilson
Thomas Walters
Stephan R. Targan
Steven R. Brant
John D. Rioux
Mauro D'Amato
Rinse K. Weersma
Subra Kugathasan
Anne M. Griffiths
John C. Mansfield
Severine Vermeire
Richard H. Duerr
Mark S. Silverberg
Jack Satsangi
Stefan Schreiber
Judy H. Cho
Vito Annese
Hakon Hakonarson
Mark J. Daly
Miles Parkes
: Nature genetics, Vol.42(12), pp.1118-1125
: Medicine (UOC)
: Springer Nature
: M01RR000425 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) 089120; WT089120/Z/09/Z / Wellcome Trust; European Commission N01HC085081 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) N01HC75150; N01-HC-85080; N01-HC-75150; N01-HC-85083; N01 HC-55222; N01HC85086; N01-HC-85086; N01-HC-85085; N01-HC-85081; N01HC55222; U01 HL080295; N01 HC015103; R01 HL087652; N01-HC-85084; N01 HC035129; N01HC85079; N01-HC-85082; N01 HC045133; N01-HC-85079 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) DK064869; DK062432; U01 DK062420; U01 DK062431; R21 DK084554; DK062413; DK062431; U01 DK062429; P30 DK063491; DK084554; DK76984; U01 DK062422; P01-DK046763; DK062429; DK062422; DK062420; DK069513; K23 DK069513; U01 DK062423; P30 DK043351; DK062423; P01 DK046763; U01 DK062413; R01 DK064869; R03 DK076984; U01 DK062432; DK 063491 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) U01DK062423 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) CZB/4/540 / Chief Scientist Office K08 AR055688-03; K08 AR055688-01A1S1; K08 AR055688-04; K08 AR055688 / NIAMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) M01 RR000425; M01-RR00425 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R01HL087652 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) G0800759 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) K08AR055688 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) G0800759; G0800675; G0600329 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission
: 01/12/2010
: English
: Journal article