Global biological sample collections from tuberculosis studies: a scoping review

Cara Adolph; Simon C Mendelsohn; Laura E Via; Leonardo Martinez; Cecilia S Lindestam Arlehamn; David M Lewinsohn; Jordi B Torrelles; Philip C Hill

doi:10.1016/j.lanmic.2025.101287

Global biological sample collections from tuberculosis studies: a scoping review

Cara Adolph, Simon C Mendelsohn, Laura E Via, Leonardo Martinez, Cecilia S Lindestam Arlehamn, David M Lewinsohn, Jordi B Torrelles Philip C Hill

The Lancet. Microbe, 101287

22/12/2025

: https://doi.org/10.1016/j.lanmic.2025.101287

https://hdl.handle.net/10523/49358

Progress in tuberculosis vaccine development is hindered by the incomplete understanding of protective immunity and other disease mechanisms. An interconnected network of sample biorepositories from tuberculosis studies could help to address these gaps. To assess the feasibility of such a resource, we conducted a scoping review of tuberculosis observational studies and vaccine clinical trials. The included studies collected at least one biological sample from tuberculosis cases, contacts, or controls and had more than 100 participants. We contacted the corresponding authors of these studies to determine the sample availability and interest in interconnected biorepositories. For the period 2014-24, we identified 104 observational studies and 18 vaccine trials that collected biological samples from 35 075 tuberculosis cases, 39 450 contacts or controls, and 45 628 trial participants across 43 countries. The commonly collected samples were blood, human genomic DNA, RNA, and sputum. Interest among the contacted investigators was high. Interconnected sample biorepositories could facilitate large-scale investigations and accelerate progress towards tuberculosis vaccine development.

(2)

pdf

PIIS26665247250021501.06 MB

Published (Version of record), Open Access

url

https://doi.org/10.1016/j.lanmic.2025.101287

Published (Version of record),

: 9926823718501891
: Global biological sample collections from tuberculosis studies: a scoping review
: Cara Adolph
Simon C Mendelsohn
Laura E Via
Leonardo Martinez
Cecilia S Lindestam Arlehamn
David M Lewinsohn
Jordi B Torrelles
Philip C Hill
: The Lancet. Microbe, 101287
: Centre for International Health
: Elsevier
: Gates Foundation (INV-058406); Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
: 22/12/2025
: Copyright © The Author(s) 2025. This work was first published in The Lancet Microbe (Elsevier). This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly attributed to the creator(s) and the source, is not altered, transformed, or built upon in any way, and a link to the Creative Commons license is provided.
: English
: Journal article