Abstract
Purpose of review: This review presents evidence for pathways that have genetic underpinnings in gout that should be prioritized for further study and therapeutic development.
Recent findings: Recent genome-wide association studies have identified molecular mechanisms in the pathogenesis of gout that converge on cell metabolism, phagocytosis of crystals and cytokine signalling.
Summary: Understanding how the gene pathways function to influence the gout flare; crystal formation, crystal deposition and the subsequent immune response and inflammation characteristic of the gout flare is critical to developing additional therapies in the gout repertoire.