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Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells
Journal article   Peer reviewed

Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells

Siva Gowri Pathmanathan, Blair Lawley, Michelle McConnell, Margaret A. Baird and Gerald W. Tannock
Anaerobe, Vol.61, pp.102112-102112
01/02/2020
DOI: https://doi.org/10.1016/j.anaerobe.2019.102112
Handle:
https://hdl.handle.net/10523/22170

Abstract

Life Sciences & Biomedicine Microbiology Science & Technology
Immuno-modulatory effects of infant gut bacteria were tested on poly(I:C) stimulated HT-29 intestinal epithelial cells. Blautia producta, Bacteroides vulgatus, Bacteroides fragilis and Bacteroides thetaiotaomicron decreased transcription of poly(I:C)-induced inflammatory genes. Modulation of basal level and poly(I:C)-induced IL-8 secretion varied between bacterial species, and between heat treated and non-heat treated bacterial cells. (C) 2019 Elsevier Ltd. All rights reserved.

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