Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23

P J Byrd; T Stankovic; C M McConville; A D Smith; P R Cooper; AMR Taylor

doi:10.1101/gr.7.1.71

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Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23

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Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23

P J Byrd, T Stankovic, C M McConville, A D Smith, P R Cooper and AMR Taylor

PCR methods and applications, Vol.7(1), pp.71-75

01/01/1997

DOI: https://doi.org/10.1101/gr.7.1.71

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https://hdl.handle.net/10523/36284

Abstract

Biochemistry & Molecular Biology

Biotechnology & Applied Microbiology

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

We have localized the human homolog of the rabbit vasopressin-activated calcium-mobilizing receptor VACM-1 to a region close to the gene For ataxia telangiectasia ATM on chromosome 11q22-23. We have determined the complete amino acid sequence of the human Hs-VACM-1 protein, which is 780 amino acids long. The human and rabbit sequences are highly conserved, differing at only seven amino acids. Northern analysis of the human gene showed expression in a wide range of human tissues. The Hs-VACM-1 gene has homology with the Caenorhabditis elegans gene Ce-cul-5, a member of a family of cullin genes that are involved in cell cycle regulation and that might, when mutated, contribute to tumor progression.

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Record Identifier: 9926529208901891
Title: Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23
Creators: P J Byrd
T Stankovic
C M McConville
A D Smith
P R Cooper
AMR Taylor
Publication Details: PCR methods and applications, Vol.7(1), pp.71-75
Academic Unit: Office of the Head of Faculty (Dentistry)
Publisher: COLD SPRING HARBOR LAB PRESS
Date published ; e-published: 01/01/1997
Language: English
Resource Type ; Subtype: Journal article