Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit

François Lamontagne; Marie-Hélène Masse; Julie Menard; Sheila Sprague; Ruxandra Pinto; Daren K. Heyland; Deborah J Cook; Marie-Claude Battista; Andrew G. Day; Gordon H. Guyatt; Salmaan Kanji; Rachael Parke; Shay P. McGuinness; Bharath-Kumar Tirupakuzhi Vijayaraghavan; Djillali Annane; Dian Cohen; Yaseen M. Arabi; Brigitte Bolduc; Nicole Marinoff; Bram Rochwerg; Tina Millen; Maureen O. Meade; Lori Hand; Irene Watpool; Rebecca Porteous; Paul J. Young; Frederick D’Aragon; Emilie P. Belley-Cote; Elaine Carbonneau; France Clarke; David M. Maslove; Miranda Hunt; Michaël Chassé; Martine Lebrasseur; François Lauzier; Sangeeta Mehta; Hector Quiroz-Martinez; Oleksa G. Rewa; Emmanuel Charbonney; Andrew J.E. Seely; Demetrios J. Kutsogiannis; Remi LeBlanc; Armand Mekontso-Dessap; Tina S. Mele; Alexis F. Turgeon; Gordon Wood; Sandeep S. Kohli; Jason Shahin; Pawel Twardowski; Neill K.J. Adhikari; LOVIT Investigators and the Canadian Critical Care Trials Group; Seton Henderson

doi:10.1056/NEJMoa2200644

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Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit

Journal article

Open access

Peer reviewed

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit

François Lamontagne, Marie-Hélène Masse, Julie Menard, Sheila Sprague, Ruxandra Pinto, Daren K. Heyland, Deborah J Cook, Marie-Claude Battista, Andrew G. Day, Gordon H. Guyatt, …

The New England journal of medicine, Vol.386(25), pp.2387-2398

23/06/2022

DOI: https://doi.org/10.1056/NEJMoa2200644

Handle:

https://hdl.handle.net/10523/20682

Abstract

Clinical Medicine

Critical Care

Critical Care General

Emergency Medicine

Emergency Medicine General

Hospital-Based Clinical Medicine

Infectious Disease

Infectious Disease General

Pulmonary

In this trial of intravenous vitamin C in adult patients with sepsis, those who received a vitamin C infusion had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo.

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Record Identifier: 9926495498301891
Title: Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit
Creators: François Lamontagne
Marie-Hélène Masse
Julie Menard
Sheila Sprague
Ruxandra Pinto
Daren K. Heyland
Deborah J Cook
Marie-Claude Battista
Andrew G. Day
Gordon H. Guyatt
Salmaan Kanji
Rachael Parke
Shay P. McGuinness
Bharath-Kumar Tirupakuzhi Vijayaraghavan
Djillali Annane
Dian Cohen
Yaseen M. Arabi
Brigitte Bolduc
Nicole Marinoff
Bram Rochwerg
Tina Millen
Maureen O. Meade
Lori Hand
Irene Watpool
Rebecca Porteous
Paul J. Young
Frederick D’Aragon
Emilie P. Belley-Cote
Elaine Carbonneau
France Clarke
David M. Maslove
Miranda Hunt
Michaël Chassé
Martine Lebrasseur
François Lauzier
Sangeeta Mehta
Hector Quiroz-Martinez
Oleksa G. Rewa
Emmanuel Charbonney
Andrew J.E. Seely
Demetrios J. Kutsogiannis
Remi LeBlanc
Armand Mekontso-Dessap
Tina S. Mele
Alexis F. Turgeon
Gordon Wood
Sandeep S. Kohli
Jason Shahin
Pawel Twardowski
Neill K.J. Adhikari
LOVIT Investigators and the Canadian Critical Care Trials Group
Seton Henderson
Publication Details: The New England journal of medicine, Vol.386(25), pp.2387-2398
Academic Unit: Anaesthesia (UOC)
Publisher: Massachusetts Medical Society
Date published ; e-published: 23/06/2022
Language: English
Resource Type ; Subtype: Journal article