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M-Protein Analysis of Streptococcus pyogenes Isolates Associated with Acute Rheumatic Fever in New Zealand
Journal article   Open access   Peer reviewed

M-Protein Analysis of Streptococcus pyogenes Isolates Associated with Acute Rheumatic Fever in New Zealand

Deborah A Williamson, Pierre R Smeesters, Andrew C Steer, John D Steemson, Adrian C H Ng, Thomas Proft, John D Fraser, Michael G Baker, Julie Morgan, Philip E Carter, …
Journal of clinical microbiology, Vol.53(11), pp.3618-3620
01/11/2015
DOI: https://doi.org/10.1128/JCM.02129-15
Handle:
https://hdl.handle.net/10523/31888

Abstract

Antigens, Bacterial - genetics Bacterial Outer Membrane Proteins - genetics Carrier Proteins - genetics Humans Molecular Epidemiology - methods Molecular Typing New Zealand - epidemiology Retrospective Studies Rheumatic Fever - epidemiology Rheumatic Fever - microbiology Streptococcal Infections - epidemiology Streptococcal Infections - microbiology Streptococcus pyogenes - classification Streptococcus pyogenes - genetics Streptococcus pyogenes - isolation & purification Streptococcus pyogenes - pathogenicity
We applied an emm cluster typing system to group A Streptococcus strains in New Zealand, including those associated with acute rheumatic fever (ARF). We observed few so-called rheumatogenic emm types but found a high proportion of emm types previously associated with pyoderma, further suggesting a role for skin infection in ARF.
url
https://doi.org/10.1128/JCM.02129-15View
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