Mechanisms of Coronary Impairment and Heart Failure Due to the Development of Pulmonary Arterial Hypertension in Insulin Resistant Rats

Mark T. Waddingham; Huiling Jin; Takashi Sonobe; Hirotsugu Tsuchimochi; Daryl O. Schwenke; Vijayakumar Sukumaran; Keiji Umetani; James T. Pearson

doi:10.18957/rr.13.6.373

Back

Mechanisms of Coronary Impairment and Heart Failure Due to the Development of Pulmonary Arterial Hypertension in Insulin Resistant Rats

Journal article

Open access

Peer reviewed

Mechanisms of Coronary Impairment and Heart Failure Due to the Development of Pulmonary Arterial Hypertension in Insulin Resistant Rats

Mark T. Waddingham, Huiling Jin, Takashi Sonobe, Hirotsugu Tsuchimochi, Daryl O. Schwenke, Vijayakumar Sukumaran, Keiji Umetani and James T. Pearson

SPring-8/SACLA Research Report, Vol.13(6), pp.373-376

26/12/2025

DOI: https://doi.org/10.18957/rr.13.6.373

Handle:

https://hdl.handle.net/10523/49411

Abstract

Coronary circulation

Myocardium

Pulmonary Arterial Hypertension

Right Ventricle

This study determined the extent that right coronary endothelial dysfunction develops in early pulmonary arterial hypertension (PAH) rats and if dysfunction is accelerated by insulin resistance. Exacerbated coronary endothelial dysfunction developed in diabetic rats during the transition to PAH and was associated with increased thrombosis and reduced right ventricle contractility.

Files and links (2)

pdf

13_3735.95 MBDownload View

Published (Version of record)CC BY V4.0, Open Access

url

https://doi.org/10.18957/rr.13.6.373View

Published (Version of record)CC BY V4.0, Open

Metrics

1 Record Views

Details

Record Identifier: 9926825661301891
Title: Mechanisms of Coronary Impairment and Heart Failure Due to the Development of Pulmonary Arterial Hypertension in Insulin Resistant Rats
Creators: Mark T. Waddingham
Huiling Jin
Takashi Sonobe
Hirotsugu Tsuchimochi
Daryl O. Schwenke
Vijayakumar Sukumaran
Keiji Umetani
James T. Pearson
Publication Details: SPring-8/SACLA Research Report, Vol.13(6), pp.373-376
Academic Unit: Physiology
Publisher: Japan Synchrotron Radiation Research Institute
Date published ; e-published: 26/12/2025
Copyright: Copyright © The Author(s) 2025. This work was first published in SPring-8/SACLA Research Report (Japan Synchrotron Radiation Research Institute). This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://www.creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, provided that the original work is properly attributed to the creator(s) and the source, a link to the Creative Commons license is provided, and any changes made are indicated.
Language: English
Resource Type ; Subtype: Journal article