Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Carl A. Anderson; Gabrielle Boucher; Charlie W. Lees; Andre Franke; Mauro D'Amato; Kent D. Taylor; James C. Lee; Philippe Goyette; Marcin Imielinski; Anna Latiano; Caroline Lagace; Regan Scott; Leila Amininejad; Suzannah Bumpstead; Leonard Baidoo; Robert N. Baldassano; Murray Barclay; Theodore M. Bayless; Stephan Brand; Carsten Buening; Jean-Frederic Colombel; Lee A. Denson; Martine De Vos; Marla Dubinsky; Cathryn Edwards; David Ellinghaus; Rudolf S. N. Fehrmann; James A. B. Floyd; Timothy Florin; Denis Franchimont; Lude Franke; Michel Georges; Juergen Glas; Nicole L. Glazer; Stephen L. Guthery; Talin Haritunians; Nicholas K. Hayward; Jean-Pierre Hugot; Gilles Jobin; Debby Laukens; Ian Lawrance; Marc Lemann; Arie Levine; Cecile Libioulle; Edouard Louis; Dermot P. McGovern; Monica Milla; Grant W. Montgomery; Katherine I. Morley; Craig Mowat; Aylwin Ng; William Newman; Roel A. Ophoff; Laura Papi; Orazio Palmieri; Laurent Peyrin-Biroulet; Julian Panes; Anne Phillips; Natalie J. Prescott; Deborah D. Proctor; Rebecca Roberts; Richard Russell; Paul Rutgeerts; Jeremy Sanderson; Miquel Sans; Philip Schumm; Frank Seibold; Yashoda Sharma; Lisa A. Simms; Mark Seielstad; A. Hillary Steinhart; Stephan R. Targan; Leonard H. van den Berg; Morten Vatn; Hein Verspaget; Thomas Walters; Cisca Wijmenga; David C. Wilson; Harm-Jan Westra; Ramnik J. Xavier; Zhen Z. Zhao; Cyriel Y. Ponsioen; Vibeke Andersen; Leif Torkvist; Maria Gazouli; Nicholas P. Anagnou; Tom H. Karlsen; Limas Kupcinskas; Jurgita Sventoraityte; John C. Mansfield; Subra Kugathasan; Mark S. Silverberg; Jonas Halfvarson; Jerome I. Rotter; Christopher G. Mathew; Anne M. Griffiths; Richard Gearry; Tariq Ahmad; Steven R. Brant; Mathias Chamaillard; Jack Satsangi; Judy H. Cho; Stefan Schreiber; Mark J. Daly; Jeffrey C. Barrett; Miles Parkes; Vito Annese; Hakon Hakonarson; Graham Radford-Smith; Richard H. Duerr; Severine Vermeire; Rinse K. Weersma; John D. Rioux

doi:10.1038/ng.764

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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Carl A. Anderson, Gabrielle Boucher, Charlie W. Lees, Andre Franke, Mauro D'Amato, Kent D. Taylor, James C. Lee, Philippe Goyette, Marcin Imielinski, Anna Latiano, …

Nature genetics, Vol.43(3), pp.246-U94

01/03/2011

DOI: https://doi.org/10.1038/ng.764

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https://hdl.handle.net/10523/32705

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 x 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.

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Record Identifier: 9926517728801891
Title: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Creators: Carl A. Anderson
Gabrielle Boucher
Charlie W. Lees
Andre Franke
Mauro D'Amato
Kent D. Taylor
James C. Lee
Philippe Goyette
Marcin Imielinski
Anna Latiano
Caroline Lagace
Regan Scott
Leila Amininejad
Suzannah Bumpstead
Leonard Baidoo
Robert N. Baldassano
Murray Barclay
Theodore M. Bayless
Stephan Brand
Carsten Buening
Jean-Frederic Colombel
Lee A. Denson
Martine De Vos
Marla Dubinsky
Cathryn Edwards
David Ellinghaus
Rudolf S. N. Fehrmann
James A. B. Floyd
Timothy Florin
Denis Franchimont
Lude Franke
Michel Georges
Juergen Glas
Nicole L. Glazer
Stephen L. Guthery
Talin Haritunians
Nicholas K. Hayward
Jean-Pierre Hugot
Gilles Jobin
Debby Laukens
Ian Lawrance
Marc Lemann
Arie Levine
Cecile Libioulle
Edouard Louis
Dermot P. McGovern
Monica Milla
Grant W. Montgomery
Katherine I. Morley
Craig Mowat
Aylwin Ng
William Newman
Roel A. Ophoff
Laura Papi
Orazio Palmieri
Laurent Peyrin-Biroulet
Julian Panes
Anne Phillips
Natalie J. Prescott
Deborah D. Proctor
Rebecca Roberts
Richard Russell
Paul Rutgeerts
Jeremy Sanderson
Miquel Sans
Philip Schumm
Frank Seibold
Yashoda Sharma
Lisa A. Simms
Mark Seielstad
A. Hillary Steinhart
Stephan R. Targan
Leonard H. van den Berg
Morten Vatn
Hein Verspaget
Thomas Walters
Cisca Wijmenga
David C. Wilson
Harm-Jan Westra
Ramnik J. Xavier
Zhen Z. Zhao
Cyriel Y. Ponsioen
Vibeke Andersen
Leif Torkvist
Maria Gazouli
Nicholas P. Anagnou
Tom H. Karlsen
Limas Kupcinskas
Jurgita Sventoraityte
John C. Mansfield
Subra Kugathasan
Mark S. Silverberg
Jonas Halfvarson
Jerome I. Rotter
Christopher G. Mathew
Anne M. Griffiths
Richard Gearry
Tariq Ahmad
Steven R. Brant
Mathias Chamaillard
Jack Satsangi
Judy H. Cho
Stefan Schreiber
Mark J. Daly
Jeffrey C. Barrett
Miles Parkes
Vito Annese
Hakon Hakonarson
Graham Radford-Smith
Richard H. Duerr
Severine Vermeire
Rinse K. Weersma
John D. Rioux
Publication Details: Nature genetics, Vol.43(3), pp.246-U94
Academic Unit: Medicine (UOC)
Publisher: Springer Nature
Grant note: 916.10.135 / NWO (ZonMW); Netherlands Organization for Scientific Research (NWO); Netherlands Organization for Health Research and Development European Community Adessium Foundation 93519031 / Netherlands Genomics Initiative Italian Society for Paediatric Gastroenterology, Hepatology and Nutrition Peninsular College of Medicine and Dentistry, Exeter University of Queensland National Association for Colitis and Crohn's disease BSIK03009 / Celiac Disease Consortium Amyotrophic Lateral Sclerosis Association Primary Children's Medical Center Foundation Italian Group for IBD Cedars-Sinai Medical Center M11-1 / Crohn's and Colitis UK; Crohn's & Colitis Foundation of America Medical Research Council UK; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) German Ministry of Education and Research through the National Genome Research Network Crohn's and Colitis Foundation of America; Crohn's & Colitis Foundation of America G0600329; G0800759; G0800675; G1002033 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) BR 1912/5-1 / Deutsche Forschungsgemeinschaft (DFG); German Research Foundation (DFG) Prinses Beatrix Fonds 90.700.281; 918.66.620 / Netherlands Organization for Scientific Research (NWO) M01-RR00425 / National Center for Research Resources (NCRR); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) P01-DK046763; DK 063491 / NIH/NIDDK; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) National Health and Medical Research Council, Australia; National Health & Medical Research Council (NHMRC) of Australia Royal Brisbane and Women's Hospital Foundation CZB/4/540 / Chief Scientist Office; Chief Scientist Office - Scotland Helmsley Foundation G0800675; G0800759; G1002033; G0600329 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) P50/05/EKMS05/62 / Else Kroner-Fresenius-Stiftung Programme Hospitalier de Recherche Clinique DK064869 / US National Institutes of Health (NIH)/NIDDK; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) 083948/Z/07/Z; WT091745/Z/10/Z; WT089120/Z/09/Z / Wellcome Trust National Institute for Health Research (NIHR) Biomedical Research Centre; National Institutes of Health Research (NIHR)
Date published ; e-published: 01/03/2011
Language: English
Resource Type ; Subtype: Journal article