Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Nikolas A. Patsopoulos; Sergio E. Baranzini; Adams Santaniello; Parisa Shoostari; Chris Cotsapas; Garrett Wong; Ashley H. Beecham; Tojo James; Joseph Replogle; Ioannis S. Vlachos; Cristin McCabe; Tune H. Pers; Aaron Brandes; Charles White; Brendan Keenan; Maria Cimpean; Phoebe Winn; Ioannis-Pavlos Panteliadis; Allison Robbins; Till F. M. Andlauer; Onigiusz Zarzycki; Bénédicte Dubois; An Goris; Helle Bach Sondergaard; Finn Sellebjerg; Per Soelberg Sorensen; Henrik Ullum; Lise Wegner Thorner; Janna Saarela; Isabelle Cournu-Rebeix; Vincent Damotte; Bertrand Fontaine; Lena Guillot-Noel; Mark Lathrop; Sandra Vukusic; Achim Berthele; Viola Pongratz; Christiane Gasperi; Christiane Graetz; Verena Grummel; Bernhard Hemmer; Muni Hoshi; Benjamin Knier; Thomas Korn; Christina M. Lill; Felix Luessi; Mark Muehlau; Frauke Zipp; Efthimios Dardiotis; Cristina Agliardi; Antonio Amoroso; Nadia Barizzone; Maria D. Benedetti; Luisa Bernardinelli; Paola Cavalla; Ferdinando Clarelli; Giancarlo Comi; Daniele Cusi; Federica Esposito; Laura Ferre; Daniela Galimberti; Clara Guaschino; Maurizio A. Leone; Vittorio Martinelli; Lucia Moiola; Marco Salvetti; Melissa Sorosina; Domizia Vecchio; Andrea Zauli; Silvia Santoro; Nicasio Mancini; Miriam Zuccala; Julia Mescheriakova; Cornelia van Duijn; Steffan D. Bos; Elisabeth G. Celius; Anne Spurkland; Manuel Comabella; Xavier Montalban; Lars Alfredsson; Izaura L. Bomfim; David Gomez-Cabrero; Jan Hillert; Maja Jagodic; Magdalena Linden; Fredrik Piehl; Ilijas Jelcic; Roland Martin; Mirela Sospedra; Amie Baker; Maria Ban; Clive Hawkins; Pirro Hysi; Seema Kalra; Fredrik Karpe; Jyoti Khadake; Genevieve Lachance; Paul Molyneux; Matthew Neville; John Thorpe; Elizabeth Bradshaw; Stacy J. Caillier; Peter Calabresi; Bruce A. C. Cree; Anne Cross; Mary Davis; Paul W. I. de Bakker; Silvia Delgado; Marieme Dembele; Keith Edwards; Kate Fitzgerald; Irene Y. Frohlich; Pierre-Antoine Gourraud; Jonathan L. Haines; Hakon Hakonarson; Dorlan Kimbrough; Noriko Isobe; Ioanna Konidari; Ellen Lathi; Michelle H. Lee; Taibo Li; David An; Andrew Zimmer; Lohith Madireddy; Clara P. Manrique; Mitja Mitrovic; Marta Olah; Ellis Patrick; Margaret A. Pericak-Vance; Laura Piccio; Cathy Schaefer; Howard Weiner; Kasper Lage; Rodney J. Scott; Jeannette Lechner-Scott; Rod Leal; Pablo Moscato; David R. Booth; Graeme J. Stewart; Stephen Vucic; Grant Pame; Michael BamettO; Deborah Mason; Lyn GriffithS; Simon Broadley; Lotti Tajouri; Alan Baxter; Mark Slee; Bruce V. Taylor; Jac Charlesworth; Trevor J. Kilpatrick; Justin Rubio; Vilija Jokubaitis; James Wiley; Helmut Butzkueven; Stephen Leslie; Allan Motyer; Jim Stankovich; William M. Carroll; Allan G. Kermode; Marzena Edrin; Murray Barclay; Laurent Peyrin-Biroulet; Mathias Chamaillard; Jean-Frederick Colombe; Mario Cottone; Anthony Croft; Renata D'Inca; Jonas Halfvarson; Katherine Hanigan; Paul Henderson; Jean-Pierre Hugot; Amir Karban; Nicholas A. Kennedy; Mohammed Azam Khan; Marc Lemann; Arie Levine; Dunecan Massey; Monica Milla; Grant W. Motoey; Sok Meng Evelyn Ng; Joannis Oikonomnou; Harald Peeters; Deborah D. Proctor; Jean-Francois Rahier; Rebecca Roberts; Paul Rutgeerts; Frank Seibold; Laura Stronati; Kirstin M. Taylor; Leif Torkvist; Kullak Ublick; Johan Van Limbergen; Andre Van Gossum; Morten H. Vatn; Hu Zhang; Wei Zhang; Peter Donnelly; Ines Barroso; Jenefer M. Blackwe; Elvira Bramon; Matthew A. Brown; Juan P. Casas; Aiden Corvin; Panos Deloukas; Audrey Duncanson; Janusz Jankowski; Hugh S. Markus; Christopher G. Mathew; Colin N. A. Palmer; Robert Plomin; Anna Rautanen; Stephen J. Sawcer; Richard C. Trembath; Ananth C. Viswanathan; Nicholas W. Wood; Chris C. A. Spencer; Gavin Band; Celine Bellenguez; Colin Freeman; Garrett Hellenthal; Eleni Giannoulatou; Matti Pirinen; Richard Pearson; Amy Strange; Zhan Sul; Damj An Vukcevic; Cordelia Langford; Sarah E. Hunt; Sarah Edkins; Rhian Gwilliam; Hannah Blackburn; Suzannah J. Bumpstead; Serge Dronov; Matthew Gillman; Emma Gray; Naomi Hammond; Alagurevathi Jayakumar; Owen T. McCann; Jennifer Liddle; Simon C. Potter; Radhi Ravindrarajah; Michelle Ricketts; Matthew Waller; Paul Weston; Sara Widaa; Pamela Whittaker; Alastair Compston; David Hafler; Hanne F. Harbo; Stephen L. Hauser; Graeme Stewart; Sandra D'Alfonso; Georgios Hadjigeorgiou; Bruce Taylor; Lisa F. Barcellos; David Booth; Rogier Hintzen; Ingrid Kockum; Filippo Martinelli-Boneschi; Jacob L. McCauley; Jorge R. Oksenberg; Annette Oturai; Stephen Sawcer; Adrian J. Ivinson; Tomas Olsson; Philip L. De Jager; Australia New Zealand IBDGC

doi:10.1126/science.aav7188

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Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Journal article

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Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Nikolas A. Patsopoulos, Sergio E. Baranzini, Adams Santaniello, Parisa Shoostari, Chris Cotsapas, Garrett Wong, Ashley H. Beecham, Tojo James, Joseph Replogle, Ioannis S. Vlachos, …

Science (American Association for the Advancement of Science), Vol.365(6460), p.1417

27/09/2019

DOI: https://doi.org/10.1126/science.aav7188

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https://hdl.handle.net/10523/25942

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Record Identifier: 9926515166101891
Title: Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
Creators: Nikolas A. Patsopoulos
Sergio E. Baranzini
Adams Santaniello
Parisa Shoostari
Chris Cotsapas
Garrett Wong
Ashley H. Beecham
Tojo James
Joseph Replogle
Ioannis S. Vlachos
Cristin McCabe
Tune H. Pers
Aaron Brandes
Charles White
Brendan Keenan
Maria Cimpean
Phoebe Winn
Ioannis-Pavlos Panteliadis
Allison Robbins
Till F. M. Andlauer
Onigiusz Zarzycki
Bénédicte Dubois
An Goris
Helle Bach Sondergaard
Finn Sellebjerg
Per Soelberg Sorensen
Henrik Ullum
Lise Wegner Thorner
Janna Saarela
Isabelle Cournu-Rebeix
Vincent Damotte
Bertrand Fontaine
Lena Guillot-Noel
Mark Lathrop
Sandra Vukusic
Achim Berthele
Viola Pongratz
Viola Pongratz
Christiane Gasperi
Christiane Graetz
Verena Grummel
Bernhard Hemmer
Muni Hoshi
Benjamin Knier
Thomas Korn
Christina M. Lill
Felix Luessi
Mark Muehlau
Frauke Zipp
Efthimios Dardiotis
Cristina Agliardi
Antonio Amoroso
Nadia Barizzone
Maria D. Benedetti
Luisa Bernardinelli
Paola Cavalla
Ferdinando Clarelli
Giancarlo Comi
Daniele Cusi
Federica Esposito
Laura Ferre
Daniela Galimberti
Clara Guaschino
Maurizio A. Leone
Vittorio Martinelli
Lucia Moiola
Marco Salvetti
Melissa Sorosina
Domizia Vecchio
Andrea Zauli
Silvia Santoro
Nicasio Mancini
Miriam Zuccala
Julia Mescheriakova
Cornelia van Duijn
Steffan D. Bos
Elisabeth G. Celius
Anne Spurkland
Manuel Comabella
Xavier Montalban
Lars Alfredsson
Izaura L. Bomfim
David Gomez-Cabrero
Jan Hillert
Maja Jagodic
Magdalena Linden
Fredrik Piehl
Ilijas Jelcic
Roland Martin
Mirela Sospedra
Amie Baker
Maria Ban
Clive Hawkins
Pirro Hysi
Seema Kalra
Fredrik Karpe
Jyoti Khadake
Genevieve Lachance
Paul Molyneux
Matthew Neville
John Thorpe
Elizabeth Bradshaw
Stacy J. Caillier
Peter Calabresi
Bruce A. C. Cree
Anne Cross
Mary Davis
Paul W. I. de Bakker
Silvia Delgado
Marieme Dembele
Keith Edwards
Kate Fitzgerald
Irene Y. Frohlich
Pierre-Antoine Gourraud
Jonathan L. Haines
Hakon Hakonarson
Dorlan Kimbrough
Noriko Isobe
Ioanna Konidari
Ellen Lathi
Michelle H. Lee
Taibo Li
David An
Andrew Zimmer
Lohith Madireddy
Clara P. Manrique
Mitja Mitrovic
Marta Olah
Ellis Patrick
Margaret A. Pericak-Vance
Laura Piccio
Cathy Schaefer
Howard Weiner
Kasper Lage
Rodney J. Scott
Jeannette Lechner-Scott
Rod Leal
Pablo Moscato
David R. Booth
Graeme J. Stewart
Stephen Vucic
Grant Pame
Michael BamettO
Deborah Mason
Lyn GriffithS
Simon Broadley
Lotti Tajouri
Alan Baxter
Mark Slee
Bruce V. Taylor
Jac Charlesworth
Trevor J. Kilpatrick
Justin Rubio
Vilija Jokubaitis
James Wiley
Helmut Butzkueven
Stephen Leslie
Allan Motyer
Jim Stankovich
William M. Carroll
Allan G. Kermode
Marzena Edrin
Murray Barclay
Laurent Peyrin-Biroulet
Mathias Chamaillard
Jean-Frederick Colombe
Mario Cottone
Anthony Croft
Renata D'Inca
Jonas Halfvarson
Katherine Hanigan
Paul Henderson
Jean-Pierre Hugot
Amir Karban
Nicholas A. Kennedy
Mohammed Azam Khan
Marc Lemann
Arie Levine
Dunecan Massey
Monica Milla
Grant W. Motoey
Sok Meng Evelyn Ng
Joannis Oikonomnou
Harald Peeters
Deborah D. Proctor
Jean-Francois Rahier
Rebecca Roberts
Paul Rutgeerts
Frank Seibold
Laura Stronati
Kirstin M. Taylor
Leif Torkvist
Kullak Ublick
Johan Van Limbergen
Andre Van Gossum
Morten H. Vatn
Hu Zhang
Wei Zhang
Peter Donnelly
Ines Barroso
Jenefer M. Blackwe
Elvira Bramon
Matthew A. Brown
Juan P. Casas
Aiden Corvin
Panos Deloukas
Audrey Duncanson
Janusz Jankowski
Hugh S. Markus
Christopher G. Mathew
Colin N. A. Palmer
Robert Plomin
Anna Rautanen
Stephen J. Sawcer
Richard C. Trembath
Ananth C. Viswanathan
Nicholas W. Wood
Chris C. A. Spencer
Gavin Band
Celine Bellenguez
Colin Freeman
Garrett Hellenthal
Eleni Giannoulatou
Matti Pirinen
Richard Pearson
Amy Strange
Zhan Sul
Damj An Vukcevic
Peter Donnelly
Cordelia Langford
Sarah E. Hunt
Sarah Edkins
Rhian Gwilliam
Hannah Blackburn
Suzannah J. Bumpstead
Serge Dronov
Matthew Gillman
Emma Gray
Naomi Hammond
Alagurevathi Jayakumar
Owen T. McCann
Jennifer Liddle
Simon C. Potter
Radhi Ravindrarajah
Michelle Ricketts
Matthew Waller
Paul Weston
Sara Widaa
Pamela Whittaker
Ines Barroso
Panos Deloukas
Christopher G. Mathew
Jenefer M. Blackwe
Matthew A. Brown
Aiden Corvin
Chris C. A. Spencer
Alastair Compston
David Hafler
Hanne F. Harbo
Stephen L. Hauser
Graeme Stewart
Sandra D'Alfonso
Georgios Hadjigeorgiou
Bruce Taylor
Lisa F. Barcellos
David Booth
Rogier Hintzen
Ingrid Kockum
Filippo Martinelli-Boneschi
Jacob L. McCauley
Jorge R. Oksenberg
Annette Oturai
Stephen Sawcer
Adrian J. Ivinson
Tomas Olsson
Philip L. De Jager
Australia New Zealand IBDGC
Publication Details: Science (American Association for the Advancement of Science), Vol.365(6460), p.1417
Academic Unit: Medicine (UOC)
Publisher: Amer Assoc Advancement Science
Grant note: G0000934 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Foundation for Research in Neurology ANR-10-COHO-002 / French government 196776; 240102 / Research Council of Norway Danish Multiple Sclerosis Society Biogen (Denmark) A/S 2011/R/1; 2015/R/10 / Italian Foundation of Multiple Sclerosis (FISM); Fondazione Italiana Sclerosi Multipla (FISM) Research Council KU Leuven; KU Leuven RG 4198-A-1; AP-3758-A-16 / National MS Society (NMSS); National Multiple Sclerosis Society RG 4680-A-1 / U.S. National Multiple Sclerosis Society; National Multiple Sclerosis Society German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent; Federal Ministry of Education & Research (BMBF) German Ministry for Education and Research; Federal Ministry of Education & Research (BMBF) Swedish Association for Persons with Neurological Disabilities AFM-Genethon R01NS096212; R01 NS049477 / NIH/NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Research Foundation Flanders; FWO Connect-Talents Award Benzon Foundation AFA insurance 085475/B/08/Z; 085475/Z/08/Z / Wellcome Trust Case Control Consortium 2 project; Wellcome Trust R01 AI059829 / NIH/NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Harvard Neuro Discovery Center Eugene Devic EDMUS Foundation against multiple sclerosis JF2138A1; RG 4680A1/1 / NMSS; National Multiple Sclerosis Society Swedish Brain Foundation Wellcome Trust R01NS088155 / NINDS/NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) 068545/Z/02 / Wellcome Trust Oslo MS association German Competence Network MS (BMBF KKNMS); Federal Ministry of Education & Research (BMBF) 861/07 / UK MS society NIHR Oxford Biomedical Research Centre Programme European Union; European Union (EU) 01ZX1614J / e:Med Programme 2142-08-0039 / Danish Council for Strategic Research; Danske Strategiske Forskningsrad (DSF) ARSEP CIC AFM; Association Francaise contre les Myopathies RC2 GM093080; R01AG036836 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA G1100125 / UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Knut and Alice Wallenberg Foundation; Knut & Alice Wallenberg Foundation Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Norwegian Bone Marrow Registry Lundbeck Foundation; Lundbeckfonden Novartis R01 ES0495103 / NIH/NIEHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) MultipleMS EU project Dutch MS Research Foundation Norwegian MS Registry and Biobank ARSEP Foundation Intel Parallel Computing Center Swedish Medical Research Council; Swedish Medical Research Council (SMRC) Sofus Carl Emil Friis og Hustru Olga Doris Friis Foundation NIHR; National Institutes of Health Research (NIHR) Inserm ATIP-Avenir Fellowship Kings College London Cambridge NIHR Biomedical Research Centre; National Institutes of Health Research (NIHR) Swedish Research Council for Health, Working Life and Welfare; Swedish Research Council for Health Working Life & Welfare (Forte) FG 1938-A-1; TA 3056-A-2; AP3758-A-16 / National Multiple Sclerosis Society
Date published ; e-published: 27/09/2019
Language: English
Resource Type ; Subtype: Journal article

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

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