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Parameterisation affects identifiability of population models
Journal article   Peer reviewed

Parameterisation affects identifiability of population models

Vittal Shivva, Julia Korell, Ian G. Tucker and Stephen B. Duffull
Journal of pharmacokinetics and pharmacodynamics, Vol.41(1), pp.81-86
01/02/2014
DOI: https://doi.org/10.1007/s10928-013-9347-8
Handle:
https://hdl.handle.net/10523/31400

Abstract

Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
Identifiability is an important aspect of model development. In this work, using a simple one compartment population pharmacokinetic model, we show that identifiability of the variances of the random effects parameters are affected by the parameterisation of the fixed effects parameters.

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