Phage capsid recognition triggers activation of a bacterial toxin-antitoxin defense system

Leah M. Smith; Peter C. Fineran

doi:10.1016/j.molcel.2022.12.020

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Phage capsid recognition triggers activation of a bacterial toxin-antitoxin defense system

Journal article

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Peer reviewed

Phage capsid recognition triggers activation of a bacterial toxin-antitoxin defense system

Leah M. Smith and Peter C. Fineran

Molecular cell, Vol.83(2), pp.165-166

19/01/2023

DOI: https://doi.org/10.1016/j.molcel.2022.12.020

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https://hdl.handle.net/10523/22410

Abstract

Zhang et al.1 reveal a previously unknown route to toxin activation whereby bacteriophage capsid proteins bind the antitoxin domain of the CapRel fused toxin-antitoxin system, triggering translational inhibition via pyrophosporylation of tRNAs and culminating in abortive infection-mediated phage resistance. Zhang et al.1 reveal a previously unknown route to toxin activation whereby bacteriophage capsid proteins bind the antitoxin domain of the CapRel fused toxin-antitoxin system, triggering translational inhibition via pyrophosporylation of tRNAs and culminating in abortive infection-mediated phage resistance.

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Details

Record Identifier: 9926495442301891
Title: Phage capsid recognition triggers activation of a bacterial toxin-antitoxin defense system
Creators: Leah M. Smith
Peter C. Fineran
Publication Details: Molecular cell, Vol.83(2), pp.165-166
Academic Unit: Microbiology and Immunology
Publisher: Elsevier Inc
Date published ; e-published: 19/01/2023
Language: English
Resource Type ; Subtype: Journal article