Phase I trial of the single-chain urokinase intrapleural LTI-01 in complicated parapneumonic effusions or empyema

Lutz Beckert; Ben Brockway; Graham Simpson; Anne Marie Southcott; Y.C. Gary Lee; Najib Rahman; Richard W. Light; Steven Shoemaker; John Gillies; Andrey A. Komissarov; Galina Florova; Timothy Ochran; William Bradley; Harrison Ndetan; Karan P. Singh; Krishna Sarva; Steven Idell

doi:10.1172/jci.insight.127470

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Phase I trial of the single-chain urokinase intrapleural LTI-01 in complicated parapneumonic effusions or empyema

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Phase I trial of the single-chain urokinase intrapleural LTI-01 in complicated parapneumonic effusions or empyema

Lutz Beckert, Ben Brockway, Graham Simpson, Anne Marie Southcott, Y.C. Gary Lee, Najib Rahman, Richard W. Light, Steven Shoemaker, John Gillies, Andrey A. Komissarov, …

JCI insight, Vol.4(10), e127470

16/05/2019

DOI: https://doi.org/10.1172/jci.insight.127470

Handle:

https://hdl.handle.net/10523/25856

Abstract

Clinical Medicine

Intrapleural single chain urokinase was well-tolerated in subjects with loculated complicated parapneumonic pleural effusions or empyema with hints of efficacy in a phase 1 trial.

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Record Identifier: 9926515051301891
Title: Phase I trial of the single-chain urokinase intrapleural LTI-01 in complicated parapneumonic effusions or empyema
Creators: Lutz Beckert
Ben Brockway
Graham Simpson
Anne Marie Southcott
Y.C. Gary Lee
Najib Rahman
Richard W. Light
Steven Shoemaker
John Gillies
Andrey A. Komissarov
Galina Florova
Timothy Ochran
William Bradley
Harrison Ndetan
Karan P. Singh
Krishna Sarva
Steven Idell
Publication Details: JCI insight, Vol.4(10), e127470
Academic Unit: Medicine (UOC)
Publisher: American Society for Clinical Investigation
Grant note: AG 18-09 / Lung Therapeutics, Inc.(LTI) UO-1 HL121841-01A1 / NIH, NHLBI NA / Lung Therapeutics, Inc. (LTI) 1R01HL130402-01A1 / NIH, NHLBI SMARTT HHSN268201100014C / NIH, NHLBI
Date published ; e-published: 16/05/2019
Language: English
Resource Type ; Subtype: Journal article