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Prediction of Torsade de Pointes From the QT Interval: Analysis of a Case Series of Amisulpride Overdoses
Journal article   Peer reviewed

Prediction of Torsade de Pointes From the QT Interval: Analysis of a Case Series of Amisulpride Overdoses

J. P. Joy, C. V. Coulter, S. B. Duffull and G. K. Isbister
Clinical pharmacology and therapeutics, Vol.90(2), pp.243-245
08/2011
DOI: https://doi.org/10.1038/clpt.2011.107
Handle:
https://hdl.handle.net/10523/32777

Abstract

Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
Electrocardiograms (ECGs) from a case series of 86 amisulpride overdose events in 66 patients were reviewed for abnormal QT intervals and torsade de pointes (TdP). Eight patients exhibited TdP. In this investigative case series, the magnitude of prolongation of the QT interval was a stronger predictor of TdP than the mere presence of a prolongation per se.

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