Pro-Arg, The Potential Anti-Diabetes Peptide, Screened from Almond by In-Silico Analysis

Xin Gu; Zhihui Cong; Di Li; Yakun Hou; Yu Fu; Bimal Chitrakar; Die Wei; Meng Xi; Tao Gao

doi:10.1007/s11130-024-01289-1

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Pro-Arg, The Potential Anti-Diabetes Peptide, Screened from Almond by In-Silico Analysis

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Pro-Arg, The Potential Anti-Diabetes Peptide, Screened from Almond by In-Silico Analysis

Xin Gu, Zhihui Cong, Di Li, Yakun Hou, Yu Fu, Bimal Chitrakar, Die Wei, Meng Xi and Tao Gao

Plant foods for human nutrition, Vol.80(1), 39

18/01/2025

DOI: https://doi.org/10.1007/s11130-024-01289-1

Handle:

https://hdl.handle.net/10523/49076

Abstract

In-silico analysis

Almond

Anti-diabetic peptides

Insulin resistance was considered to be the most important clinical phenotype of type 2 diabetes (T2DM). Almond is a widely-consumed nut and long-term intake was beneficial to alleviating insulin resistance in patients with T2DM. Hence, screening of anti-diabetic peptides from almond proteins was feasible based on the effectiveness of peptides in the treatment of T2DM. Pro-Arg (PR), a potential anti-diabetic peptide screened from almonds proteins using in-silico technology and cell experiment, upregulated the phosphorylation levels of IRS1, PI3K, AKT, and translocation of GLUT4, and showed potential to target AKT1 in molecular simulation, suggesting PR mediated the activation of IRS1/PI3K/AKT/GLUT4 signaling pathway by targeting AKT1 to alleviate insulin resistance. Consequently, PR was the potential anti-diabetes peptide from almond proteins and showed the potential application as a candidate drug for alleviating T2DM.

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Record Identifier: 9926815824201891
Title: Pro-Arg, The Potential Anti-Diabetes Peptide, Screened from Almond by In-Silico Analysis
Creators: Xin Gu
Zhihui Cong
Di Li
Yakun Hou
Yu Fu
Bimal Chitrakar
Die Wei
Meng Xi
Tao Gao
Publication Details: Plant foods for human nutrition, Vol.80(1), 39
Academic Unit: Food Science
Publisher: Springer Nature
Grant note: KJQN202301255 / Science and Technology Research Program of the Chongqing Municipal Education Commission
Date published ; e-published: 18/01/2025
Copyright: Copyright © The Author(s) 2025. All rights reserved. This work was first published in Plant Foods for Human Nutrition (Springer Nature). The open access link to the subscription article is provided under the Springer Nature SharedIt Content-Sharing Initiative (https://www.springernature.com/gp/researchers/sharedit) making the view-only full-text article freely and legally accessible to anyone for research purposes and private study via the link: https://rdcu.be/eTU7n.
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Language: English
Resource Type ; Subtype: Journal article