Pyroglutamic acidosis: an under-recognised cause of high anion gap metabolic acidosis with multi-factorial aetiology

Yassar Alamri; Polly Davison; Charlotte Reay; John Geddes; Christopher Florkowski

Back

Pyroglutamic acidosis: an under-recognised cause of high anion gap metabolic acidosis with multi-factorial aetiology

Journal article

Open access

Peer reviewed

Pyroglutamic acidosis: an under-recognised cause of high anion gap metabolic acidosis with multi-factorial aetiology

Yassar Alamri, Polly Davison, Charlotte Reay, John Geddes and Christopher Florkowski

New Zealand journal of medical laboratory science, Vol.79(2), pp.65-66

01/07/2025

Handle:

https://hdl.handle.net/10523/47448

Abstract

Anion gap

Pyroglutamate

5-oxoproline

Paracetamol

Anti-epileptic drug

case study

Pyroglutamic acidosis (PGA) remains under-recognised among practising clinicians. Predisposing factors are common. We present a recent case of pyroglutamic acidosis and highlight the role of drug-drug/drug-body interactions, as well as the necessity of good communication between clinicians at the bedside, and scientists at the bench.

Files and links (2)

pdf

NZJMLS V.79 NO. 2 July 202510.22 MBDownload View

Published (Version of record)CC BY V4.0, Open Access

url

Link to journal issueView

Published (Version of record)CC BY V4.0, Open

Metrics

5 File views/ downloads

10 Record Views

Details

Record Identifier: 9926760433901891
Title: Pyroglutamic acidosis: an under-recognised cause of high anion gap metabolic acidosis with multi-factorial aetiology
Creators: Yassar Alamri
Polly Davison
Charlotte Reay
John Geddes
Christopher Florkowski
Publication Details: New Zealand journal of medical laboratory science, Vol.79(2), pp.65-66
Academic Unit: Medicine (UOC)
Publisher: New Zealand Institute of Medical Laboratory Science
Date published ; e-published: 01/07/2025
Copyright: Copyright © The Author(s) 2025. This work was first published in New Zealand Journal of Medical Laboratory Science (New Zealand Institute of Medical Laboratory Science). This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://www.creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, provided that the original work is properly attributed to the creator(s) and the source, a link to the Creative Commons license is provided, and any changes made are indicated.
Language: English
Resource Type ; Subtype: Journal article