Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Natalie Lorenz; Timothy K. C. Ho; Reuben McGregor; Mark R. Davies; Deborah A. Williamson; Jason K. Gurney; Pierre R. Smeesters; Michael G. Baker; Nicole J. Moreland

doi:10.1093/cid/ciab180

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Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Journal article

Open access

Peer reviewed

Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Natalie Lorenz, Timothy K. C. Ho, Reuben McGregor, Mark R. Davies, Deborah A. Williamson, Jason K. Gurney, Pierre R. Smeesters, Michael G. Baker and Nicole J. Moreland

Clinical infectious diseases, Vol.73(12), pp.2322-2325

26/02/2021

DOI: https://doi.org/10.1093/cid/ciab180

Handle:

https://hdl.handle.net/10523/25087

Appears in Cancer and Chronic Conditions (C3)

Abstract

rheumatic fever

group A Streptococcus

immune priming

emm-type

emm-cluster

Cancer and Chronic Conditions (C3) Collection

C3: Rheumatic Heart Disease

Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

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Record Identifier: 9926514910801891
Title: Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever
Creators: Natalie Lorenz
Timothy K. C. Ho
Reuben McGregor
Mark R. Davies
Deborah A. Williamson
Jason K. Gurney
Pierre R. Smeesters
Michael G. Baker
Nicole J. Moreland
Publication Details: Clinical infectious diseases, Vol.73(12), pp.2322-2325
Academic Unit: Public Health (UOW)
Publisher: Oxford University Press
Grant note: This work was supported by the Auckland Medical Research Foundation and the Maurice Wilkins Centre for Biodiscovery. The Rheumatic Fever Risk Factors study, from which samples were obtained, was funded by the Heath Research Council of New Zealand (HRC) Rheumatic Fever Research Partnership (Ministry of Health, Te Puni Kōkiri, Cure Kids, Heart Foundation, and HRC).
Date published ; e-published: 26/02/2021
Comment: The published version is not available in full-text in OUR Archive. Where available, a link to the published version is provided (check the DOI and/or the Files and links section). The full-text item may be open access on the publisher's website. An earlier version of the work (such as authors' accepted manuscript following peer-review or unreviewed preprint/author's original version) may be available in the Files and links section of this record. Alternatively, readers may have subscription access to the full-text from the publisher.
Language: English
Resource Type ; Subtype: Journal article