Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Melissa A. Munn-Chernoff; Emma C. Johnson; Yi-Ling Chou; Jonathan R. I. Coleman; Laura M. Thornton; Raymond K. Walters; Zeynep Yilmaz; Jessica H. Baker; Christopher Hubel; Scott Gordon; Sarah E. Medland; Hunna J. Watson; Helena A. Gaspar; Julien Bryois; Anke Hinney; Virpi M. Leppa; Manuel Mattheisen; Stephan Ripke; Shuyang Yao; Paola Giusti-Rodriguez; Ken B. Hanscombe; Roger A. H. Adan; Lars Alfredsson; Tetsuya Ando; Ole A. Andreassen; Wade H. Berrettini; Ilka Boehm; Claudette Boni; Vesna Boraska Perica; Katharina Buehren; Roland Burghardt; Matteo Cassina; Sven Cichon; Maurizio Clementi; Roger D. Cone; Philippe Courtet; Scott Crow; James J. Crowley; Unna N. Danner; Oliver S. P. Davis; Martina de Zwaan; George Dedoussis; Daniela Degortes; Janiece E. DeSocio; Danielle M. Dick; Dimitris Dikeos; Christian Dina; Monika Dmitrzak-Weglarz; Elisa Docampo; Laramie E. Duncan; Karin Egberts; Stefan Ehrlich; Georgia Escaramis; Tonu Esko; Xavier Estivill; Anne Farmer; Angela Favaro; Fernando Fernandez-Aranda; Manfred M. Fichter; Krista Fischer; Manuel Foecker; Lenka Foretova; Andreas J. Forstner; Monica Forzan; Christopher S. Franklin; Steven Gallinger; Ina Giegling; Johanna Giuranna; Fragiskos Gonidakis; Philip Gorwood; Monica Gratacos Mayora; Sebastien Guillaume; Yiran Guo; Hakon Hakonarson; Konstantinos Hatzikotoulas; Joanna Hauser; Johannes Hebebrand; Sietske G. Helder; Stefan Herms; Beate Herpertz-Dahlmann; Wolfgang Herzog; Laura M. Huckins; James I. Hudson; Hartmut Imgart; Hidetoshi Inoko; Vladimir Janout; Susana Jimenez-Murcia; Antonio Julia; Gursharan Kalsi; Deborah Kaminska; Leila Karhunen; Andreas Karwautz; Martien J. H. Kas; James L. Kennedy; Anna Keski-Rahkonen; Kirsty Kiezebrink; Youl-Ri Kim; Kelly L. Klump; Gun Peggy S. Knudsen; Maria C. La Via; Stephanie Le Hellard; Robert D. Levitan; Dong Li; Lisa Lilenfeld; Bochao Danae Lin; Jolanta Lissowska; Jurjen Luykx; Pierre J. Magistretti; Mario Maj; Katrin Mannik; Sara Marsal; Christian R. Marshall; Morten Mattingsdal; Sara McDevitt; Peter McGuffin; Andres Metspalu; Ingrid Meulenbelt; Nadia Micali; Karen Mitchell; Alessio Maria Monteleone; Palmiero Monteleone; Benedetta Nacmias; Marie Navratilova; Ioanna Ntalla; Julie K. O'Toole; Roel A. Ophoff; Leonid Padyukov; Aarno Palotie; Jacques Pantel; Hana Papezova; Dalila Pinto; Raquel Rabionet; Anu Raevuori; Nicolas Ramoz; Ted Reichborn-Kjennerud; Valdo Ricca; Samuli Ripatti; Franziska Ritschel; Marion Roberts; Alessandro Rotondo; Dan Rujescu; Filip Rybakowski; Paolo Santonastaso; Andre Scherag; Stephen W. Scherer; Ulrike Schmidt; Nicholas J. Schork; Alexandra Schosser; Jochen Seitz; Lenka Slachtova; P. Eline Slagboom; Margarita C. T. Slof-Op't Landt; Agnieszka Slopien; Sandro Sorbi; Beat Swiatkowska; Jin P. Szatkiewicz; Ioanna Tachmazidou; Elena Tenconi; Alfonso Tortorella; Federica Tozzi; Janet Treasure; Artemis Tsitsika; Marta Tyszkiewicz-Nwafor; Konstantinos Tziouvas; Annemarie A. van Elburg; Eric F. van Furth; Gudrun Wagner; Esther Walton; Elisabeth Widen; Eleftheria Zeggini; Stephanie Zerwas; Stephan Zipfel; Andrew W. Bergen; Joseph M. Boden; Harry Brandt; Steven Crawford; Katherine A. Halmi; L. John Horwood; Craig Johnson; Allan S. Kaplan; Walter H. Kaye; James Mitchell; Catherine M. Olsen; John F. Pearson; Nancy L. Pedersen; Michael Strober; Thomas Werge; David C. Whiteman; D. Blake Woodside; Jakob Grove; Anjali K. Henders; Janne T. Larsen; Richard Parker; Liselotte V. Petersen; Jennifer Jordan; Martin A. Kennedy; Andreas Birgegard; Paul Lichtenstein; Claes Norring; Mikael Landen; Preben Bo Mortensen; Renato Polimanti; Jeanette N. McClintick; Amy E. Adkins; Fazil Aliev; Silviu-Alin Bacanu; Anthony Batzler; Sarah Bertelsen; Joanna M. Biernacka; Tim B. Bigdeli; Li-Shiun Chen; Toni-Kim Clarke; Franziska Degenhardt; Anna R. Docherty; Alexis C. Edwards; Jerome C. Foo; Louis Fox; Josef Frank; Laura M. Hack; Annette M. Hartmann; Sarah M. Hartz; Stefanie Heilmann-Heimbach; Colin Hodgkinson; Per Hoffmann; Jouke-Jan Hottenga; Bettina Konte; Jari Lahti; Marius Lahti-Pulkkinen; Dongbing Lai; Lannie Ligthart; Anu Loukola; Brion S. Maher; Hamdi Mbarek; Andrew M. McIntosh; Matthew B. McQueen; Jacquelyn L. Meyers; Yuri Milaneschi; Teemu Palviainen; Roseann E. Peterson; Euijung Ryu; Nancy L. Saccone; Jessica E. Salvatore; Sandra Sanchez-Roige; Melanie Schwandt; Richard Sherva; Fabian Streit; Jana Strohmaier; Nathaniel Thomas; Jen-Chyong Wang; Bradley T. Webb; Robbee Wedow; Leah Wetherill; Amanda G. Wills; Hang Zhou; Jason D. Boardman; Danfeng Chen; Doo-Sup Choi; William E. Copeland; Robert C. Culverhouse; Norbert Dahmen; Louisa Degenhardt; Benjamin W. Domingue; Mark A. Frye; Wolfgang Gabel; Caroline Hayward; Marcus Ising; Margaret Keyes; Falk Kiefer; Gabriele Koller; John Kramer; Samuel Kuperman; Susanne Lucae; Michael T. Lynskey; Wolfgang Maier; Karl Mann; Satu Maennistoe; Bertram Mueller-Myhsok; Alison D. Murray; John I. Nurnberger; Ulrich Preuss; Katri Raikkonen; Maureen D. Reynolds; Monika Ridinger; Norbert Scherbaum; Marc A. Schuckit; Michael Soyka; Jens Treutlein; Stephanie H. Witt; Norbert Wodarz; Peter Zill; Daniel E. Adkins; Dorret I. Boomsma; Laura J. Bierut; Sandra A. Brown; Kathleen K. Bucholz; E. Jane Costello; Harriet De Wit; Nancy Diazgranados; Johan G. Eriksson; Lindsay A. Farrer; Tatiana M. Foroud; Nathan A. Gillespie; Alison M. Goate; David Goldman; Richard A. Grucza; Dana B. Hancock; Kathleen Mullan Harris; Victor Hesselbrock; John K. Hewitt; Christian J. Hopfer; William G. Iacono; Eric O. Johnson; Victor M. Karpyak; Kenneth S. Kendler; Henry R. Kranzler; Kenneth Krauter; Penelope A. Lind; Matt McGue; James MacKillop; Pamela A. F. Madden; Hermine H. Maes; Patrik K. E. Magnusson; Elliot C. Nelson; Markus M. Noethen; Abraham A. Palmer; Brenda W. J. H. Penninx; Bernice Porjesz; John P. Rice; Marcella Rietschel; Brien P. Riley; Richard J. Rose; Pei-Hong Shen; Judy Silberg; Michael C. Stallings; Ralph E. Tarter; Michael M. Vanyukov; Scott Vrieze; Tamara L. Wall; John B. Whitfield; Hongyu Zhao; Benjamin M. Neale; Tracey D. Wade; Andrew C. Heath; Grant W. Montgomery; Nicholas G. Martin; Patrick F. Sullivan; Jaakko Kaprio; Gerome Breen; Joel Gelernter; Howard J. Edenberg; Cynthia M. Bulik; Arpana Agrawal

doi:10.1111/adb.12880

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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Journal article

Peer reviewed

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Melissa A. Munn-Chernoff, Emma C. Johnson, Yi-Ling Chou, Jonathan R. I. Coleman, Laura M. Thornton, Raymond K. Walters, Zeynep Yilmaz, Jessica H. Baker, Christopher Hubel, Scott Gordon, …

Addiction biology, Vol.26(1), pp.e12880-n/a

01/2021

DOI: https://doi.org/10.1111/adb.12880

Handle:

https://hdl.handle.net/10523/25323

Abstract

Biochemistry & Molecular Biology

Life Sciences & Biomedicine

Science & Technology

Substance Abuse

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r(g)], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from similar to 2400 to similar to 537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (r(g) = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (r(g) = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (r(g) = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (r(gs) = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.

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Record Identifier: 9926514690701891
Title: Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
Creators: Melissa A. Munn-Chernoff
Emma C. Johnson
Yi-Ling Chou
Jonathan R. I. Coleman
Laura M. Thornton
Raymond K. Walters
Zeynep Yilmaz
Jessica H. Baker
Christopher Hubel
Scott Gordon
Sarah E. Medland
Hunna J. Watson
Helena A. Gaspar
Julien Bryois
Anke Hinney
Virpi M. Leppa
Manuel Mattheisen
Stephan Ripke
Shuyang Yao
Paola Giusti-Rodriguez
Ken B. Hanscombe
Roger A. H. Adan
Lars Alfredsson
Tetsuya Ando
Ole A. Andreassen
Wade H. Berrettini
Ilka Boehm
Claudette Boni
Vesna Boraska Perica
Katharina Buehren
Roland Burghardt
Matteo Cassina
Sven Cichon
Maurizio Clementi
Roger D. Cone
Philippe Courtet
Scott Crow
James J. Crowley
Unna N. Danner
Oliver S. P. Davis
Martina de Zwaan
George Dedoussis
Daniela Degortes
Janiece E. DeSocio
Danielle M. Dick
Dimitris Dikeos
Christian Dina
Monika Dmitrzak-Weglarz
Elisa Docampo
Laramie E. Duncan
Karin Egberts
Stefan Ehrlich
Georgia Escaramis
Tonu Esko
Xavier Estivill
Anne Farmer
Angela Favaro
Fernando Fernandez-Aranda
Manfred M. Fichter
Krista Fischer
Manuel Foecker
Lenka Foretova
Andreas J. Forstner
Monica Forzan
Christopher S. Franklin
Steven Gallinger
Ina Giegling
Johanna Giuranna
Fragiskos Gonidakis
Philip Gorwood
Monica Gratacos Mayora
Sebastien Guillaume
Yiran Guo
Hakon Hakonarson
Konstantinos Hatzikotoulas
Joanna Hauser
Johannes Hebebrand
Sietske G. Helder
Stefan Herms
Beate Herpertz-Dahlmann
Wolfgang Herzog
Laura M. Huckins
James I. Hudson
Hartmut Imgart
Hidetoshi Inoko
Vladimir Janout
Susana Jimenez-Murcia
Antonio Julia
Gursharan Kalsi
Deborah Kaminska
Leila Karhunen
Andreas Karwautz
Martien J. H. Kas
James L. Kennedy
Anna Keski-Rahkonen
Kirsty Kiezebrink
Youl-Ri Kim
Kelly L. Klump
Gun Peggy S. Knudsen
Maria C. La Via
Stephanie Le Hellard
Robert D. Levitan
Dong Li
Lisa Lilenfeld
Bochao Danae Lin
Jolanta Lissowska
Jurjen Luykx
Pierre J. Magistretti
Mario Maj
Katrin Mannik
Sara Marsal
Christian R. Marshall
Morten Mattingsdal
Sara McDevitt
Peter McGuffin
Andres Metspalu
Ingrid Meulenbelt
Nadia Micali
Karen Mitchell
Alessio Maria Monteleone
Palmiero Monteleone
Benedetta Nacmias
Marie Navratilova
Ioanna Ntalla
Julie K. O'Toole
Roel A. Ophoff
Leonid Padyukov
Aarno Palotie
Jacques Pantel
Hana Papezova
Dalila Pinto
Raquel Rabionet
Anu Raevuori
Nicolas Ramoz
Ted Reichborn-Kjennerud
Valdo Ricca
Samuli Ripatti
Franziska Ritschel
Marion Roberts
Alessandro Rotondo
Dan Rujescu
Filip Rybakowski
Paolo Santonastaso
Andre Scherag
Stephen W. Scherer
Ulrike Schmidt
Nicholas J. Schork
Alexandra Schosser
Jochen Seitz
Lenka Slachtova
P. Eline Slagboom
Margarita C. T. Slof-Op't Landt
Agnieszka Slopien
Sandro Sorbi
Beat Swiatkowska
Jin P. Szatkiewicz
Ioanna Tachmazidou
Elena Tenconi
Alfonso Tortorella
Federica Tozzi
Janet Treasure
Artemis Tsitsika
Marta Tyszkiewicz-Nwafor
Konstantinos Tziouvas
Annemarie A. van Elburg
Eric F. van Furth
Gudrun Wagner
Esther Walton
Elisabeth Widen
Eleftheria Zeggini
Stephanie Zerwas
Stephan Zipfel
Andrew W. Bergen
Joseph M. Boden
Harry Brandt
Steven Crawford
Katherine A. Halmi
L. John Horwood
Craig Johnson
Allan S. Kaplan
Walter H. Kaye
James Mitchell
Catherine M. Olsen
John F. Pearson
Nancy L. Pedersen
Michael Strober
Thomas Werge
David C. Whiteman
D. Blake Woodside
Jakob Grove
Anjali K. Henders
Janne T. Larsen
Richard Parker
Liselotte V. Petersen
Jennifer Jordan
Martin A. Kennedy
Andreas Birgegard
Paul Lichtenstein
Claes Norring
Mikael Landen
Preben Bo Mortensen
Renato Polimanti
Jeanette N. McClintick
Amy E. Adkins
Fazil Aliev
Silviu-Alin Bacanu
Anthony Batzler
Sarah Bertelsen
Joanna M. Biernacka
Tim B. Bigdeli
Li-Shiun Chen
Toni-Kim Clarke
Franziska Degenhardt
Anna R. Docherty
Alexis C. Edwards
Jerome C. Foo
Louis Fox
Josef Frank
Laura M. Hack
Annette M. Hartmann
Sarah M. Hartz
Stefanie Heilmann-Heimbach
Colin Hodgkinson
Per Hoffmann
Jouke-Jan Hottenga
Bettina Konte
Jari Lahti
Marius Lahti-Pulkkinen
Dongbing Lai
Lannie Ligthart
Anu Loukola
Brion S. Maher
Hamdi Mbarek
Andrew M. McIntosh
Matthew B. McQueen
Jacquelyn L. Meyers
Yuri Milaneschi
Teemu Palviainen
Roseann E. Peterson
Euijung Ryu
Nancy L. Saccone
Jessica E. Salvatore
Sandra Sanchez-Roige
Melanie Schwandt
Richard Sherva
Fabian Streit
Jana Strohmaier
Nathaniel Thomas
Jen-Chyong Wang
Bradley T. Webb
Robbee Wedow
Leah Wetherill
Amanda G. Wills
Hang Zhou
Jason D. Boardman
Danfeng Chen
Doo-Sup Choi
William E. Copeland
Robert C. Culverhouse
Norbert Dahmen
Louisa Degenhardt
Benjamin W. Domingue
Mark A. Frye
Wolfgang Gabel
Caroline Hayward
Marcus Ising
Margaret Keyes
Falk Kiefer
Gabriele Koller
John Kramer
Samuel Kuperman
Susanne Lucae
Michael T. Lynskey
Wolfgang Maier
Karl Mann
Satu Maennistoe
Bertram Mueller-Myhsok
Alison D. Murray
John I. Nurnberger
Ulrich Preuss
Katri Raikkonen
Maureen D. Reynolds
Monika Ridinger
Norbert Scherbaum
Marc A. Schuckit
Michael Soyka
Jens Treutlein
Stephanie H. Witt
Norbert Wodarz
Peter Zill
Daniel E. Adkins
Dorret I. Boomsma
Laura J. Bierut
Sandra A. Brown
Kathleen K. Bucholz
E. Jane Costello
Harriet De Wit
Nancy Diazgranados
Johan G. Eriksson
Lindsay A. Farrer
Tatiana M. Foroud
Nathan A. Gillespie
Alison M. Goate
David Goldman
Richard A. Grucza
Dana B. Hancock
Kathleen Mullan Harris
Victor Hesselbrock
John K. Hewitt
Christian J. Hopfer
William G. Iacono
Eric O. Johnson
Victor M. Karpyak
Kenneth S. Kendler
Henry R. Kranzler
Kenneth Krauter
Penelope A. Lind
Matt McGue
James MacKillop
Pamela A. F. Madden
Hermine H. Maes
Patrik K. E. Magnusson
Elliot C. Nelson
Markus M. Noethen
Abraham A. Palmer
Brenda W. J. H. Penninx
Bernice Porjesz
John P. Rice
Marcella Rietschel
Brien P. Riley
Richard J. Rose
Pei-Hong Shen
Judy Silberg
Michael C. Stallings
Ralph E. Tarter
Michael M. Vanyukov
Scott Vrieze
Tamara L. Wall
John B. Whitfield
Hongyu Zhao
Benjamin M. Neale
Tracey D. Wade
Andrew C. Heath
Grant W. Montgomery
Nicholas G. Martin
Patrick F. Sullivan
Jaakko Kaprio
Gerome Breen
Joel Gelernter
Howard J. Edenberg
Cynthia M. Bulik
Arpana Agrawal
Publication Details: Addiction biology, Vol.26(1), pp.e12880-n/a
Academic Unit: Office of the Dean (UOC); Pathology and Molecular Medicine (UOC); Psychological Medicine (UOC)
Publisher: Wiley
Grant note: MC_UU_00007/10 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
Date published ; e-published: 01/2021
Language: English
Resource Type ; Subtype: Journal article

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

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