Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium

Riyaz S. Patel; Vinicius Tragante; Amand F. Schmidt; Raymond O. McCubrey; Michael Holmes; Laurence J. Howe; Kenan Direk; Axel Akerblom; Karin Leander; Salim S. Virani; Karol A. Kaminski; Jochen D. Muehlschlegel; Hooman Allayee; Peter Almgren; Maris Alver; Ekaterina Baranova; Hassan Behloui; Bram Boeckx; Peter S. Braund; Lutz P. Breitling; Graciela Delgado; Nubia E. Duarte; Marie-Pierre Dube; Line Dufresne; Niclas Eriksson; Luisa Foco; Markus Scholz; Crystel M. Gijsberts; Charlotte Glinge; Yan Gong; Jaana Hartiala; Mahyar Heydarpour; Jaroslav A. Hubacek; Marcus Kleber; Daniel Kofink; Salma Kotti; Pekka Kuukasjarvi; Vei-Vei Lee; Andreas Leiherer; Petra A. Lenzini; Daniel Levin; Leo-Pekka Lyytikainen; Nicola Martinelli; Ute Mons; Christopher P. Nelson; Kjell Nikus; Anna P. Pilbrow; Rafal Ploski; Yan Sun; Michael W. T. Tanck; W. H. Wilson Tang; Stella Trompet; Sander W. van der Laan; Jessica Van Setten; Ragnar O. Vilmundarson; Chiara Viviani Anselmi; Efthymia Vlachopoulou; Lawien Al Ali; Eric Boerwinkle; Carlo Briguori; John F. Carlquist; Kathryn F. Carruthers; Gavino Casu; John Deanfield; Panos Deloukas; Frank Dudbridge; Thomas Engstrom; Natalie Fitzpatrick; Kim Fox; Bruna Gigante; Stefan James; Marja-Liisa Lokki; Paulo A. Lotufo; Nicola Marziliano; Ify R. Mordi; Joseph B. Muhlestein; Christopher Newton-Cheh; Jan Pitha; Christoph H. Saely; Ayman Samman-Tahhan; Pratik B. Sandesara; Andrej Teren; Adam Timmis; Frans Van de Werf; Els Wauters; Arthur A. M. Wilde; Ian Ford; David J. Stott; Ale Algra; Maria G. Andreassi; Diego Ardissino; Benoit J. Arsenault; Christie M. Ballantyne; Thomas O. Bergmeijer; Connie R. Bezzina; Simon C. Body; Eric H. Boersma; Peter Bogaty; Michiel L. Bots; Hermann Brenner; Jasper J. Brugts; Ralph Burkhardt; Clara Carpeggiani; Gianluigi Condorelli; Rhonda M. Cooper-DeHoff; Sharon Cresci; Nicolas Danchin; Ulf de Faire; Robert N. Doughty; Heinz Drexel; James C. Engert; Keith A. A. Fox; Domenico Girelli; Diederick E. Grobbee; Emil Hagstrom; Stanley L. Hazen; Claes Held; Harry Hemingway; Imo E. Hoefer; G. Kees Hovingh; Reza Jabbari; Julie A. Johnson; J. Wouter Jukema; Marcin P. Kaczor; Mika Kahonen; Jiri Kettner; Marek Kiliszek; Olaf H. Klungel; Bo Lagerqvist; Diether Lambrechts; Jari O. Laurikka; Terho Lehtimaki; Daniel Lindholm; B. K. Mahmoodi; Anke H. Maitland-van der Zee; Ruth McPherson; Olle Melander; Andres Metspalu; Anna Niemcunowicz-Janica; Oliviero Olivieri; Grzegorz Opolski; Colin N. Palmer; Gerard Pasterkamp; Carl J. Pepine; Alexandre C. Pereira; Louise Pilote; Arshed A. Quyyumi; A. Mark Richards; Marek Sanak; Agneta Siegbahn; Tabassome Simon; Juha Sinisalo; J. Gustav Smith; John A. Spertus; Steen Stender; Alexandre F. R. Stewart; Wojciech Szczeklik; Anna Szpakowicz; Jean-Claude Tardif; Jurrien M. ten Berg; Jacob Tfelt-Hansen; George Thanassoulis; Joachim Thiery; Christian Torp-Pedersen; Yolanda van der Graaf; Frank L. J. Visseren; Johannes Waltenberger; Peter E. Weeke; Pim Van der Harst; Chim C. Lang; Naveed Sattar; Vicky A. Cameron; Jeffrey L. Anderson; James M. Brophy; Guillaume Pare; Benjamin D. Horne; Winfried Marz; Lars Wallentin; Nilesh J. Samani; Aroon D. Hingorani; Folkert W. Asselbergs

doi:10.1161/CIRCGEN.119.002470

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Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium

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Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium

Riyaz S. Patel, Vinicius Tragante, Amand F. Schmidt, Raymond O. McCubrey, Michael Holmes, Laurence J. Howe, Kenan Direk, Axel Akerblom, Karin Leander, Salim S. Virani, …

Circulation. Genomic and precision medicine, Vol.12(4), pp.e002470-e002470

01/04/2019

DOI: https://doi.org/10.1161/CIRCGEN.119.002470

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https://hdl.handle.net/10523/28684

Abstract

Cardiac & Cardiovascular Systems

Cardiovascular System & Cardiology

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

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Record Identifier: 9926515144801891
Title: Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium
Creators: Riyaz S. Patel
Vinicius Tragante
Amand F. Schmidt
Raymond O. McCubrey
Michael Holmes
Laurence J. Howe
Kenan Direk
Axel Akerblom
Karin Leander
Salim S. Virani
Karol A. Kaminski
Jochen D. Muehlschlegel
Hooman Allayee
Peter Almgren
Maris Alver
Ekaterina Baranova
Hassan Behloui
Bram Boeckx
Peter S. Braund
Lutz P. Breitling
Graciela Delgado
Nubia E. Duarte
Marie-Pierre Dube
Line Dufresne
Niclas Eriksson
Luisa Foco
Markus Scholz
Crystel M. Gijsberts
Charlotte Glinge
Yan Gong
Jaana Hartiala
Mahyar Heydarpour
Jaroslav A. Hubacek
Marcus Kleber
Daniel Kofink
Salma Kotti
Pekka Kuukasjarvi
Vei-Vei Lee
Andreas Leiherer
Petra A. Lenzini
Daniel Levin
Leo-Pekka Lyytikainen
Nicola Martinelli
Ute Mons
Christopher P. Nelson
Kjell Nikus
Anna P. Pilbrow
Rafal Ploski
Yan Sun
Michael W. T. Tanck
W. H. Wilson Tang
Stella Trompet
Sander W. van der Laan
Jessica Van Setten
Ragnar O. Vilmundarson
Chiara Viviani Anselmi
Efthymia Vlachopoulou
Lawien Al Ali
Eric Boerwinkle
Carlo Briguori
John F. Carlquist
Kathryn F. Carruthers
Gavino Casu
John Deanfield
Panos Deloukas
Frank Dudbridge
Thomas Engstrom
Natalie Fitzpatrick
Kim Fox
Bruna Gigante
Stefan James
Marja-Liisa Lokki
Paulo A. Lotufo
Nicola Marziliano
Ify R. Mordi
Joseph B. Muhlestein
Christopher Newton-Cheh
Jan Pitha
Christoph H. Saely
Ayman Samman-Tahhan
Pratik B. Sandesara
Andrej Teren
Adam Timmis
Frans Van de Werf
Els Wauters
Arthur A. M. Wilde
Ian Ford
David J. Stott
Ale Algra
Maria G. Andreassi
Diego Ardissino
Benoit J. Arsenault
Christie M. Ballantyne
Thomas O. Bergmeijer
Connie R. Bezzina
Simon C. Body
Eric H. Boersma
Peter Bogaty
Michiel L. Bots
Hermann Brenner
Jasper J. Brugts
Ralph Burkhardt
Clara Carpeggiani
Gianluigi Condorelli
Rhonda M. Cooper-DeHoff
Sharon Cresci
Nicolas Danchin
Ulf de Faire
Robert N. Doughty
Heinz Drexel
James C. Engert
Keith A. A. Fox
Domenico Girelli
Diederick E. Grobbee
Emil Hagstrom
Stanley L. Hazen
Claes Held
Harry Hemingway
Imo E. Hoefer
G. Kees Hovingh
Reza Jabbari
Julie A. Johnson
J. Wouter Jukema
Marcin P. Kaczor
Mika Kahonen
Jiri Kettner
Marek Kiliszek
Olaf H. Klungel
Bo Lagerqvist
Diether Lambrechts
Jari O. Laurikka
Terho Lehtimaki
Daniel Lindholm
B. K. Mahmoodi
Anke H. Maitland-van der Zee
Ruth McPherson
Olle Melander
Andres Metspalu
Anna Niemcunowicz-Janica
Oliviero Olivieri
Grzegorz Opolski
Colin N. Palmer
Gerard Pasterkamp
Carl J. Pepine
Alexandre C. Pereira
Louise Pilote
Arshed A. Quyyumi
A. Mark Richards
Marek Sanak
Agneta Siegbahn
Tabassome Simon
Juha Sinisalo
J. Gustav Smith
John A. Spertus
Steen Stender
Alexandre F. R. Stewart
Wojciech Szczeklik
Anna Szpakowicz
Jean-Claude Tardif
Jurrien M. ten Berg
Jacob Tfelt-Hansen
George Thanassoulis
Joachim Thiery
Christian Torp-Pedersen
Yolanda van der Graaf
Frank L. J. Visseren
Johannes Waltenberger
Peter E. Weeke
Pim Van der Harst
Chim C. Lang
Naveed Sattar
Vicky A. Cameron
Jeffrey L. Anderson
James M. Brophy
Guillaume Pare
Benjamin D. Horne
Winfried Marz
Lars Wallentin
Nilesh J. Samani
Aroon D. Hingorani
Folkert W. Asselbergs
Publication Details: Circulation. Genomic and precision medicine, Vol.12(4), pp.e002470-e002470
Academic Unit: Medicine (UOC)
Publisher: Lippincott Williams & Wilkins
Grant note: 2001 D 032 / Established Clinical Investigator of the Netherlands Heart Foundation 5P01HL101398-02; 1P20HL113451-01; 1R56HL126558-01; 1RF-1AG051633-01; R01 NS064162-01; R01 HL89650-01; HL095479-01; 1U10HL110302-01; 1DP3DK094346-01; 2P01HL086773-06A1 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Heart and Stroke Foundation of Alberta HSFC; Heart & Stroke Foundation of Canada British Heart Foundation Leipzig Research Center for Civilization Diseases (LIFE) Dutch Top Institute Pharma Mondriaan Project European Research Council; European Research Council (ERC) NN402083939 / Polish Ministry of Science and Higher Education; Ministry of Science and Higher Education, Poland Health Research Council; Health Research Council of New Zealand R0133169; R01ES021801; R01MD010358; R01ES025786; R01HL103866; R01DK106000; R01HL126827; P20HL113452; P01HL098055; P01HL076491; R01HL103931 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Swedish Research Council Aarno Koskelo Foundation Barts Charity 072960/Z/03/Z; 084726/Z/08/Z; 084727/Z/08/Z; 085475/Z/08/Z; 085475/B/08/Z / Wellcome Trust PE-2013-02356818 / Italian Ministry of Health; Ministry of Health, Italy Waldburg-Zeil Clinics Isny Swedish Foundation for Strategic Research; Swedish Foundation for Humanities & Social Sciences University of Ottawa Heart Institute Servier Scania county Pfizer TYH7215; TKK2012005; TYH2012209; TYH2014312 / Helsinki University Central Hospital special government funds French Caisse Nationale d'Assurance Maladie Chief Scientist Office, Scotland; Chief Scientist Office - Scotland EU IMI-SUMMIT programme 2R01DK075787-06A1 / ERA-CVD grant Detectin-HF 201668; 305739 / 7th Framework Program (AtheroRemo) of the European Union; European Union (EU); Marie Curie Actions Netherlands Heart Foundation Merck Frost Canada Swedish Council for Work Life and Social Research; Swedish Research Council for Health Working Life & Welfare (Forte) Willy-Robert-Pitzer Foundation Italian Ministry of Education, University, and Research (MIUR); Ministry of Education, Universities and Research (MIUR) Free State of Saxony Bristol Myers Squibb; Bristol-Myers Squibb Wellcome Trust FS/18/23/33512 / British Heart Foundation Intermediate Clinical Research Fellowship FAST-MI (French Registry of Acute ST-Elevation or non-ST-elevation Myocardial Infarction) 294609 / European Research Council (ERC) European Union; European Union (EU) LURM (Laboratorio Universitario di Ricerca Medica) Research Center, University of Verona Abbott Laboratories Sanofi Aventis; Sanofi-Aventis 2001D019; 2003T302; 2007B202; CVON 2012-10 / Netherlands Heart Foundation AG051633 / National Institutes of Health/National Institutes of Aging Cariverona Foundation; Fondazione Cariverona Swedish Heart-Lung Foundation Quebec (HSFC) University of Florida Opportunity Fund Skane University Hospital in Lund 116074 / UCL Hospitals NIHR Biomedical Research Centre, EU/EFPIA Innovative Medicines Initiative 2 Joint Undertaking BigData@Heart grant 692145 / EU; European Union (EU) 05-CVD / Leducq Foundation FS/14/76/30933 / British Heart Foundation Intermediate Fellowship 01KL1802; 2014-2020.4.01.15-0012 / European Union; European Union (EU) Heart and Stroke Foundation of Yukon National Institute for Health Research University College London Hospitals Bio-medical Research Center 294609 / European Research Council Advanced Grant; European Research Council (ERC) Heart and Stroke Foundation of NWT Nunavut PCL 17/07 / NHS Education of Scotland/Chief Scientist Office Postdoctoral Clinical Lectureship; Chief Scientist Office - Scotland Pfizer Canada; Pfizer Cresci R01 NR013396 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Swedish National Health Service 01GD9820/0; 01ER0814 / German Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) Heart and Stroke Foundation; Heart & Stroke Foundation of Canada UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) P50 HL077113 / National Institutes of Health: Washington University School of Medicine SCCOR National Institute for Health Research (NIHR); National Institutes of Health Research (NIHR) Crafoord Foundation Stockholm County Council 050-060-810 / Netherlands Genomics Initiative (Netherlands Consortium for Healthy Aging) R13 0001 06 / National Centre for Research and Development (NCBiR); National Centre for Research & Development, Poland BASF Pharma; BASF Fonds de recherche du Quebec-Sante (FRQS); Fonds de recherche du Quebec (FRQ); Fonds de recherche du Quebec - Sante (FRQS) Veneto Region; Regione Veneto IUT20-60; IUT24-6; PUT1660; PUT735 / Estonian Research Council Heart Foundation of New Zealand NIH-GIANT Center for Translational Molecular Medicine (CTMM COHFAR) 01KL1802 / European Union's Horizon 2020 research and innovation programme under the ERA-NET Co-fund action Heart and Stroke Foundation of British Columbia Abraham J. AMP; Phyllis Katz Foundation (Atlanta, GA) Canadian Institutes of Health Research (CIHR) 223004 / European commission; European Union (EU); European Commission Joint Research Centre Epidemiologia e Genetica della Morte Improvvisa in Sardegna Genome Canada 2013/09/B/NZ5/00770 / National Science Centre; National Science Centre, Poland U01-GM074492; R01 HL074730 / National Institute of Health Pharmacogenomics Research Network grant Medical University of Warsaw Genome Quebec National Institute for Health Research Oxford Biomedical Research Center; National Institutes of Health Research (NIHR) Finnish Foundation for Cardiovascular research 402 529139 / National Science Center (Poland); National Science Centre, Poland FRSQ; Fonds de recherche du Quebec (FRQ); Fonds de recherche du Quebec - Sante (FRQS) PG/18/5033837 / BHF; British Heart Foundation Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) A. Fox/R01 HL 098601 / National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 00023001 / MH, Czech Republic Italian Ministry of Research's Fund for Basic Research Nova Scotia, Ontario European Regional Development Fund (ERDF); European Union (EU) 2015583WMX / Italian Ministry of Education, University and Research; Ministry of Education, Universities and Research (MIUR)
Date published ; e-published: 01/04/2019
Language: English
Resource Type ; Subtype: Journal article