Abstract
alpha-Calcitonin gene related peptide (alpha CGRP) inhibitors are important medicinal targets due to their ability to produce antimigraine effects, thus, the discovery of long-acting alpha CGRP inhibitors is of significant interest. Herein we report the synthesis of an isotopically labelled version of the well-known CGRP receptor antagonist, alpha CGRP(8-37), as well as lipidated alpha CGRP(8-37) with comparable antagonistic activity. These isotopically labelled peptides can be employed in assays to determine the metabolic stability of the lipidated alpha CGRP(8-37) and compare this with the stability of known alpha CGRP(8-37).