Abstract
The spirocyclic motif is abundant in natural products and provides an ideal three-dimensional template to interact with biological targets. With significant attention historically expended on the synthesis of flat-heterocyclic compound libraries, methods to access the less-explored three-dimensional medicinal-chemical space will continue to increase in demand. Herein, we highlight by reaction class the common strategies used to construct the spirocyclic centres embedded in a series of well-studied natural products.
1 Introduction
2 Cycloadditions
3 Palladium-Catalysed Coupling Reactions
4 Conjugate Additions
5 Imines, Aminals, and Hemiaminal Ethers
6 Mannich-Type Reactions
7 Oxidative Dearomatisation
8 Alkylation
9 Organometallic Additions
10 Conclusions