Abstract
•Pain and tinnitus are associated with prediction errors in all sensory cortices except the olfactory and gustatory cortex.•The different senses may create a unified integrated percept via the parahippocampal ‘context’ area.•when one sensory domain is deprived, the other senses may provide the parahippocampal area with the most likely sound or somatosensory sensation to fill in the gap, applying a duck test approach.•This novel concept paves the way to develop novel treatments for pain and tinnitus, using multisensory modulation or via parahippocampal targeting.
Chronic neuropathic pain and chronic tinnitus have been likened to phantom percepts, in which a complete or partial sensory deafferentation results in a filling in of the missing information derived from memory. 150 participants, 50 with tinnitus, 50 with chronic pain and 50 healthy controls underwent a resting state EEG. Source localized current density is recorded from all the sensory cortices (olfactory, gustatory, somatosensory, auditory, vestibular, visual) as well as the parahippocampal area. Functional connectivity by means of lagged phase synchronization is also computed between these regions of interest. Pain and tinnitus are associated with gamma band activity, reflecting prediction errors, in all sensory cortices except the olfactory and gustatory cortex. Functional connectivity identifies theta frequency connectivity between each of the sensory cortices except the chemical senses to the parahippocampus, but not between the individual sensory cortices. When one sensory domain is deprived, the other senses may provide the parahippocampal ‘contextual’ area with the most likely sound or somatosensory sensation to fill in the gap, applying an abductive ‘duck test’ approach, i.e., based on stored multisensory congruence. This novel concept paves the way to develop novel treatments for pain and tinnitus, using multisensory (i.e. visual, vestibular, somatosensory, auditory) modulation with or without associated parahippocampal targeting.