The emergence and impact of the M1<sub>UK</sub> lineage on invasive Group A Streptococcus disease in Aotearoa New Zealand

Anna Vesty; Xiaoyun Ren; Prachi Sharma; Natalie Lorenz; Thomas Proft; Allan Hardaker; Christina Straub; Julie Morgan; Audrey Tiong; Anneka Anderson; Rachel H Webb; Julie Bennett; Philip E Carter; Nicole J Moreland

doi:10.1093/ofid/ofae457

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The emergence and impact of the M1<sub>UK</sub> lineage on invasive Group A Streptococcus disease in Aotearoa New Zealand

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The emergence and impact of the M1_UK lineage on invasive Group A Streptococcus disease in Aotearoa New Zealand

Anna Vesty, Xiaoyun Ren, Prachi Sharma, Natalie Lorenz, Thomas Proft, Allan Hardaker, Christina Straub, Julie Morgan, Audrey Tiong, Anneka Anderson, …

Open forum infectious diseases, Vol.11(8), ofae457

09/08/2024

DOI: https://doi.org/10.1093/ofid/ofae457

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https://hdl.handle.net/10523/41281

Abstract

Group A Streptococcus

emm1

invasive group A streptococcal disease

M1 UK

M1_UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen SpeA. We show M1_UK is now the dominant invasive emm1 lineage in New Zealand and is genomically related to community infections, suggesting measures that effectively prevent GAS-pharyngitis in children could reduce invasive disease.

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Record Identifier: 9926557355401891
Title: The emergence and impact of the M1_UK lineage on invasive Group A Streptococcus disease in Aotearoa New Zealand
Creators: Anna Vesty
Xiaoyun Ren
Prachi Sharma
Natalie Lorenz
Thomas Proft
Allan Hardaker
Christina Straub
Julie Morgan
Audrey Tiong
Anneka Anderson
Rachel H Webb
Julie Bennett
Philip E Carter
Nicole J Moreland
Publication Details: Open forum infectious diseases, Vol.11(8), ofae457
Academic Unit: Public Health (UOW)
Publisher: Oxford University Press
Grant note: Genomic sequencing was conducted by the Next Generation Sequencing Laboratory at The Institute of Environmental Science and Research, funded by the New Zealand Ministry of Health and Genomics Aotearoa (ID 2004).
Date published ; e-published: 09/08/2024
Copyright: Copyright © 2024 The Author(s). This work was first published in Open Forum Infectious Diseases (Oxford University Press). This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly attributed to the creator(s) and the source, is not altered, transformed, or built upon in any way, and a link to the Creative Commons license is provided.
Language: English
Resource Type ; Subtype: Journal article

The emergence and impact of the M1UK lineage on invasive Group A Streptococcus disease in Aotearoa New Zealand

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The emergence and impact of the M1_UK lineage on invasive Group A Streptococcus disease in Aotearoa New Zealand